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Carola Hunte Profile Page
Carola Hunte


Lab: Prof. Dr. Carola Hunte
Department: BIOSS Centre for Biological Signalling Studies
Institute for Biochemistry and Biology
Address: Stefan-Meier-Str. 17
79104 Freiburg
Phone: +49 761 2035279
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
BIOSS Excellence Cluster : Member
PhD positions available: YES
Research Area: Protein Structure and Function
Research Interests: Structure, mechanism and function of medically relevant membrane proteins


Education & Training: 1982 – 1989 Study of Biology/Diploma, University of Bielefeld, Germany, University of Exeter, UK, University of Bonn, Germany
1993 Dr. rer. nat. University of Bonn
Employment & Experience: 1993 - 1994 Scientific Assistant at the Institute of Agricultural Botany, University of Bonn
1995 - 1999 Postdoctoral fellow at the Max Planck Institute of Biophysics with Prof. Dr. H. Michel
2000 - 2007 Group Leader, Max Planck Institute of Biophysics, Frankfurt/M., Germany
2007 - 2010 Chair in Membrane Biology, University of Leeds, UK
2/2010-present W3-Professor for Biochemistry / Structural Biology at the Centre for Biological Signalling Studies (bioss) / Institute for Biochemistry and Molecular Biology at the University of Freiburg, Germany
2014 - present Prodean of Research, Faculty of Medicine, University of Freiburg
Scientific Activities: 1997- present Member, German Association of Biochemistry and Molecular Biology (GBM)
2001 – 2009 Member of the „Faculty of 1000“, Focus: „Structural Biology, Section: Membrane Proteins & Energy Transduction“
2004 - 2008 Co-opted member of the „Centre for Membrane Proteomics“, Johann Wolfgang Goethe-Universität Frankfurt
2004 - 2007 Member, Macromolecular Crystallography Review Committee, European Synchrotron Radiation Facility (ESRF), France
2006 - present Member of the Editorial Board Biochimica et Biophysica Acta - Bioenergetics
2006 – present Deputy speaker of the Bioenergetics Section of the German Association of Biochemistry and Molecular Biology (GBM)
2010 Chair of the Gordon Conference of Ligand Recognition & Molecular Gating
2011/2013 Scientific co-organizer of the Cold Spring Harbor Asia Conference on Membrane Proteins: Structure and Function
2006 - Principal Investigator, Centre of Excellence Frankfurt ‘Macromolecular Complexes’


Honors and Awards:

1985-1986    Undergraduate Studies Fellowship from the German Academic Exchange Program
1987-1989    Scientific Fellowship of the German National Academic Foundation
2002            Federation of European Biochemical Societies (FEBS) award: The Anniversary Prize of the Society of Biochemistry and Molecular Biology
2007            Boris Rajewsky-Prize Biophysics
2009            Invitation for full professor, Chair in Biochemistry, University of Bayreuth; declined


Selected Publications:

Birth D, Kao WC, Hunte C. Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action. Nat Commun. 2014 Jun 4;5:4029. doi: 10.1038/ncomms5029. Abstract

Hunte C, Zickermann V und Brandt U (2010) Functional modules and structural basis of conformational coupling in mitochondrial complex I. Science 329, 448-451, published online 1 July 2010 Abstract

Solmaz SR and Hunte C (2008) Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer. J Biol. Chem. 283, 17542-17549. Abstract

Screpanti E, Padan E, Rimon A, Michel H, Hunte C (2006) Crucial steps in the structure determination of the Na+/H+ antiporter NhaA in its native conformation. J. Mol. Biol. 362, 192-202. Abstract
Hunte C, Screpanti E, Venturi M, Rimon A, Padan E, Michel H (2005) Structure of a Na+/H+ antiporter and insights into mechanism of action and regulation by pH. Nature 435, 1197-1202. Abstract

Pfeiffer K, Gohil V, Stuart RA, Hunte C, Brandt U, Greenberg ML, Schägger H (2003) Cardiolipin stabilizes respiratory chain supercomplexes. J. Biol. Chem. 278, 52873-52880. Abstract

Palsdottir H, Lojero GC, Trumpower BL, Hunte C (2003) Structure of the yeast cytochrome bc1 complex with a hydroxyquinone anion Qo inhibitor bound. J. Biol. Chem. 278, 31303-31311. Abstract

Lange C, Hunte C (2002) Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c. Proc. Natl. Acad. Sci. USA  99, 2800-2805. Abstract

Lange C, Nett JH, Trumpower BL, Hunte C (2001) Specific roles of tightly bound phospholipids in the yeast cytochrome bc1 complex structure. EMBO J. 20, 6591-6600. Abstract

Hunte C, Köpke J, Lange C, Roßmanith T, Michel H (2000) Structure at 2.3 A resolution of the cytochrome bc1 complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment. Structure 8, 669-684. Abstract

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