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Contact
| Lab: | Prof. Dr. Carola Hunte |
| Department: | BIOSS Centre for Biological Signalling Studies Institute for Biochemistry and Biology |
| Address: | Stefan-Meier-Str. 17 79104 Freiburg |
| Phone: | +49 761 2035279 |
| E-mail: | This e-mail address is being protected from spambots. You need JavaScript enabled to view it |
| Lab homepage: | www.biochemie.uni-freiburg.de/ag/hunte |
| BIOSS Excellence Cluster: | Member |
| PhD positions available: | YES |
| Web: | www.bioss.uni-freiburg.de/cms/hunte-en.html |
| Research Area: | Protein Structure and Function |
| Research Interests: | Structure, mechanism and function of medically relevant membrane proteins |
CV
| Education & Training: | 1982 – 1989 Study of Biology/Diploma, University of Bielefeld, Germany, University of Exeter, UK, University of Bonn, Germany 1993 Dr. rer. nat. University of Bonn |
| Employment & Experience: | 1993 - 1994 Scientific Assistant at the Institute of Agricultural Botany, University of Bonn 1995 - 1999 Postdoctoral fellow at the Max Planck Institute of Biophysics with Prof. Dr. H. Michel 2000 - 2007 Group Leader, Max Planck Institute of Biophysics, Frankfurt/M., Germany 2007 - 2010 Chair in Membrane Biology, University of Leeds, UK 2/2010-present W3-Professor for Biochemistry / Structural Biology at the Centre for Biological Signalling Studies (bioss) / Institute for Biochemistry and Molecular Biology at the University of Freiburg, Germany 2014 - present Prodean of Research, Faculty of Medicine, University of Freiburg |
| Scientific Activities: | 1997- present Member, German Association of Biochemistry and Molecular Biology (GBM) 2001 – 2009 Member of the „Faculty of 1000“, Focus: „Structural Biology, Section: Membrane Proteins & Energy Transduction“ 2004 - 2008 Co-opted member of the „Centre for Membrane Proteomics“, Johann Wolfgang Goethe-Universität Frankfurt 2004 - 2007 Member, Macromolecular Crystallography Review Committee, European Synchrotron Radiation Facility (ESRF), France 2006 - present Member of the Editorial Board Biochimica et Biophysica Acta - Bioenergetics 2006 – present Deputy speaker of the Bioenergetics Section of the German Association of Biochemistry and Molecular Biology (GBM) 2010 Chair of the Gordon Conference of Ligand Recognition & Molecular Gating 2011/2013 Scientific co-organizer of the Cold Spring Harbor Asia Conference on Membrane Proteins: Structure and Function 2006 - Principal Investigator, Centre of Excellence Frankfurt ‘Macromolecular Complexes’ |
Honors
| Honors and Awards: | 1985-1986 Undergraduate Studies Fellowship from the German Academic Exchange Program |
Publications
| Selected Publications: | Birth D, Kao WC, Hunte C. Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action. Nat Commun. 2014 Jun 4;5:4029. doi: 10.1038/ncomms5029. Abstract Hunte C, Zickermann V und Brandt U (2010) Functional modules and structural basis of conformational coupling in mitochondrial complex I. Science 329, 448-451, published online 1 July 2010 Abstract Solmaz SR and Hunte C (2008) Structure of complex III with bound cytochrome c in reduced state and definition of a minimal core interface for electron transfer. J Biol. Chem. 283, 17542-17549. Abstract Screpanti E, Padan E, Rimon A, Michel H, Hunte C (2006) Crucial steps in the structure determination of the Na+/H+ antiporter NhaA in its native conformation. J. Mol. Biol. 362, 192-202. Abstract
Hunte C, Screpanti E, Venturi M, Rimon A, Padan E, Michel H (2005) Structure of a Na+/H+ antiporter and insights into mechanism of action and regulation by pH. Nature 435, 1197-1202. Abstract
Pfeiffer K, Gohil V, Stuart RA, Hunte C, Brandt U, Greenberg ML, Schägger H (2003) Cardiolipin stabilizes respiratory chain supercomplexes. J. Biol. Chem. 278, 52873-52880. Abstract Palsdottir H, Lojero GC, Trumpower BL, Hunte C (2003) Structure of the yeast cytochrome bc1 complex with a hydroxyquinone anion Qo inhibitor bound. J. Biol. Chem. 278, 31303-31311. Abstract Lange C, Hunte C (2002) Crystal structure of the yeast cytochrome bc1 complex with its bound substrate cytochrome c. Proc. Natl. Acad. Sci. USA 99, 2800-2805. Abstract Lange C, Nett JH, Trumpower BL, Hunte C (2001) Specific roles of tightly bound phospholipids in the yeast cytochrome bc1 complex structure. EMBO J. 20, 6591-6600. Abstract Hunte C, Köpke J, Lange C, Roßmanith T, Michel H (2000) Structure at 2.3 A resolution of the cytochrome bc1 complex from the yeast Saccharomyces cerevisiae co-crystallized with an antibody Fv fragment. Structure 8, 669-684. Abstract |
SGBM PhD students
| SGBM PhD students: | CIBSS Track: Nikolas Groß (since May 2019) |
