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Michael Köttgen Profile Page
Michael Köttgen


Lab: Prof. Dr. Michael Köttgen
Department: Department of Medicine
Renal Division - ZKF
Address: Breisacherstr. 66
79106 Freiburg
Phone: +49 761 270 32990 (office)
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
PhD positions available: YES
Research Area: Molecular Medicine
Research Interests: Physiological and pathological functions of proteins involved in monogenic and complex genetic diseases, polycystic kidney disease, gout, TRP channels, calcium signaling, biology of cilia.


Education & Training: 1997 M.D., School of Medicine, Albert-Ludwigs-University Freiburg, Germany
1997 Doctoral degree in Physiology, Albert-Ludwigs-University Freiburg, Germany
Dissertation: pH regulation in colon carcinoma cells (summa cum laude)
1997 Visiting scientist (3 months), Cellular and Molecular Physiology (Yale
University, Dr. G. Giebisch, advisor)
Employment & Experience: 1997-1998 Residency, Department of Nephrology, University Hospital Freiburg (Dr.P.Schollmeyer)
1998-2000 Postdoctoral Fellow, Institute of Physiology, University of Freiburg(Dr.R.Greger, advisor)
2000-2004 Postdoctoral Fellow, Department of Nephrology, University Hospital Freiburg (Dr. G. Walz, advisor)
2004-2007 Postdoctoral Fellow, Department of Biological Chemistry, Johns Hopkins University, Baltimore (Dr. C. Montell/ Dr. T. Watnick, advisors)
2007-2009 Research Associate/Junior Faculty – Department of Biological Chemistry,
Johns Hopkins University, Baltimore
2009 Offers for tenure track faculty positions in the Department of Physiology and
Biophysics, Case Western Reserve University and in the Department of
Nephrology, University of Maryland (declined).
2010 Adjunct Professor, Johns Hopkins University School of Medicine, Baltimore,
MD, USA – Department of Nephrology
2/2010 Professor (W3, position accepted), University Hospital Freiburg, Germany –
Department of Nephrology
Scientific Activities: Editorial activities

Ad hoc reviewer: Nature, Cell, Nature Genetics, Nature Cell Biology, Nature Neuroscience, PNAS, EMBO Journal, EMBO Reports, FASEB Journal, Development, Pflugers Archive, ...

Reviewer: DFG, Swiss National Science Foundation, National Kidney Foundation-USA, Department of Defense, ASBS, USA. Associate Editor: Nephron Physiology


Honors and Awards:

1997 Award of the Scientific Society Freiburg for the best doctoral thesis
2002 Travel scholarship for the FASEB Summer Research Conference “Calcium and cell function” in Salt Lake City
2005 Young Investigator Travel Award, ERA-EDTA
2005 PKD Foundation Research Fellowship
2005 Poster award: FASEB Summer Research Conference "Polycystic Kidney Disease"
2007 National Kidney Foundation "Young Investigator Award"
2008 Young Investigator Career Development Grant, PKD Foundation
2009 German Researcher Relocation Program Award, Alfried Krupp von Bohlen und Halbach Foundation
2010 Cozzarelli Prize, Proceedings of the National Academy of Sciences, USA
2010     Head of DFG-funded Clinical Research Unit 201 (KFO 201): Polycystic Kidney Disease– from Model Organisms to Novel Therapies
2015    Vice-Speaker of DFG-funded Collaborative Research Center CRC 1140: KIDGEM: Kidney Disease – From Genes to Mechanisms


Selected Publications:

Hofherr A, Wagner C, Watnick T, Köttgen M. (2016) Targeted rescue of a polycystic kidney disease mutation by lysosomal inhibition. Kidney Int. doi:10.1016/j.kint.2015.11.015  Abstract

Hofherr A*, Wagner C*, Fedeles S, Somlo S, Köttgen M. (2014) N-glycosylation determines the abundance of the transient receptor potential channel TRPP2. J Biol Chem, 289(21):14854-67. Abstract

Woodward OM*, Tukaye DN*, Cui J, Greenwell P, Constantoulakis LM, Parker BS, Rao A, Köttgen M, Maloney PC, and Guggino WB. (2013) Gout-causing Q141K mutation in ABCG2 leads to instability of the nucleotide-binding domain and can be corrected with small molecules. Proc Natl Acad Sci U S A 110, 5223-5228. Abstract

Köttgen, M.*, Hofherr, A.*, Li, W.*, Chu, K., Cook, S., Montell, C., and Watnick, T. (2011) Drosophila Sperm Swim Backwards in the Female Reproductive Tract and Are Activated via TRPP2 Ion Channels, PLoS One 6, e20031. Abstract

Boehlke, C.*, Kotsis, F.*, Patel, V.*, Braeg, S., Voelker, H., Bredt, S., Beyer, T., Janusch, H., Hamann, C., Godel, M., Muller, K., Herbst, M., Hornung, M., Doerken, M., Köttgen, M., Nitschke, R., Igarashi, P., Walz, G., and Kuehn, E. W. (2010) Primary cilia regulate mTORC1 activity and cell size through Lkb1, Nat Cell Biol 12, 1115-1122. Abstract

Woodward, O. M.*, Köttgen, A.*, Coresh, J., Boerwinkle, E., Guggino, W. B., and Köttgen, M. (2009) Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout, Proc Natl Acad Sci U S A 106, 10338-10342. Abstract

Wegierski, T.*, Steffl, D.*, Kopp, C.*, Tauber, R., Buchholz, B., Nitschke, R., Kuehn, E. W., Walz, G., and Köttgen, M. (2009) TRPP2 channels regulate apoptosis through the Ca2+ concentration in the endoplasmic reticulum, EMBO J 28, 490-499. Abstract

Köttgen, M.*, Buchholz, B.*, Garcia-Gonzalez, M. A., Kotsis, F., Fu, X., Doerken, M., Boehlke, C., Steffl, D., Tauber, R., Wegierski, T., Nitschke, R., Suzuki, M., Kramer-Zucker, A., Germino, G. G., Watnick, T., Prenen, J., Nilius, B., Kuehn, E. W., and Walz, G. (2008) TRPP2 and TRPV4 form a polymodal sensory channel complex, J Cell Biol 182, 437-447. Abstract

Köttgen, M
.*, Benzing, T.*, Simmen, T., Tauber, R., Buchholz, B., Feliciangeli, S., Huber, T. B., Schermer, B., Kramer-Zucker, A., Hopker, K., Simmen, K. C., Tschucke, C. C., Sandford, R., Kim, E., Thomas, G., and Walz, G. (2005) Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation, EMBO J 24, 705-716. Abstract

Köttgen, M., Loffler, T., Jacobi, C., Nitschke, R., Pavenstadt, H., Schreiber, R., Frische, S., Nielsen, S., and Leipziger, J. (2003) P2Y6 receptor mediates colonic NaCl secretion via differential activation of cAMP-mediated transport, J Clin Invest 111, 371-379. Abstract

* equal contribution

SGBM PhD students

SGBM PhD students:


Track 2:
Alexis Hofherr (06/2009 - 05/2014)

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