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Hans-Georg Koch Profile Page
Hans-Georg Koch


Lab: Prof. Dr. Hans-Georg Koch
Department: Institute of Biochemistry and Molecular Biology
Address: Stefan-Meier-Str. 17
Phone: 0049 761 203 5250
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
PhD positions available: YES
Research Area: Protein Structure and Function
Research Interests: Targeting, integration and assembly of bacterial membrane proteins


Education & Training: 1985-87 Pre-Diploma in Biology, Göttingen University
1987-91 Diploma in Biology, Bonn University
1994 Dr.rer.nat. in Microbiology, Bonn University
2002 Habilitation in Biochemistry, Freiburg University
Employment & Experience: 1992 Visiting Research Fellow in Biochemistry, University of Cordoba, Spain
1994-1997 Post-Doctoral Researcher, University of Pennsylvania, Philadelphia, USA
1997-2002 Post-Doc in Biochemistry, Albert-Ludwigs-University Freiburg, Germany
2002-present Group Leader, Albert-Ludwigs-University Freiburg, Germany
Scientific Activities: 1990-present Member, German Association of General and Applied Microbiology
1996-1997 Scientific Advisor, Lew-Tilney Fellowship Program, University of Pennsylvania,
Philadelphia, USA
2000-2006 Member, Selection Committee Studienstiftung des Deutschen Volkes
2000-present ad hoc Reviewer for scientific journals (e.g. EMBO J., Mol. Microbiol., J. Cell
2002-present Reviewer for the ‚Agence Nationale de la Recherche’ France; National
Science Foundation USA’; ‘Deutsche Forschungsgemeinschaft’; ‘Israel
Science Foundation’ and ‘Netherlands Organisation for Scientific Research
2003-present Member, Editorial Committee ‘Biochemistry’, Foxwell & Davies Publishers
2004-present Member Mentoring Program University Freiburg Medical School


Honors and Awards:

1992 Research Fellowship, Gesellschaft f. Biotechnologische Forschung
1993-1994 PhD Fellowship, Studienstiftung des Deutschen Volkes
1994-1997 Post-Doctoral Fellowship, National Institute of Health, USA
1997 Young Scientist Award, Internat. Society for Photosynthesis
1997 Young Scientist Grant, Fed. Europ. Microbiol. Societies (FEMS)
2004-2006 Member of the Collaborative Research Centre 388
since 2007 Member German-French PhD College on Membranes and Membrane Proteins
since 2008 Member International Graduate School on Membranes and Membrane
Proteins (DFG-GRK1478)
since 2008 Member Research Group on Ribosomal Exit Tunnel Ligands (DFG-FOR967)
since 2008 Member Research Group on Bacterial Membrane Protein Dynamics (DFGFOR929)


Selected Publications:

Denks K, Sliwinski N, Erichsen V, Borodkina B, Origi A, Koch HG. The signal recognition particle contacts uL23 and scans substrate translation inside the ribosomal tunnel. Nat  Microbiol. 2017 Jan 30;2:16265.  Abstract

Braig D, Nero TL, Koch HG, Kaiser B, Wang X, Thiele JR, Morton CJ, Zeller J, Kiefer J, Potempa LA, Mellett NA, Miles LA, Du XJ, Meikle PJ, Huber-Lang M, Stark GB, Parker MW, Peter K, Eisenhardt SU. Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites. Nat Commun. 2017 Jan 23;8:14188.  Abstract

Kuhn P, Draycheva A, Vogt A, Petriman NA, Sturm L, Drepper F, Warscheid B, Wintermeyer W, Koch HG. Ribosome binding induces repositioning of the signal recognition particle receptor on the translocon. J Cell Biol. 2015 Oct 12;211(1):91-104.  Abstract

Hannemann L, Suppanz I, Ba Q, MacInnes K, Drepper F, Warscheid B, Koch HG. Redox Activation of the Universally Conserved ATPase YchF by Thioredoxin 1. Antioxid Redox Signal. 2016 Jan 20;24(3):141-56.  Abstract

Welte T, Kudva R, Kuhn P, Sturm L, Braig D, Müller M, Warscheid B, Drepper F, Koch HG. Promiscuous targeting of polytopic membrane proteins to SecYEG or YidC by the Escherichia coli signal recognition particle. Mol Biol Cell. 2012 Feb;23(3):464-79.  Abstract

Mircheva M, Boy D, Weiche B, Hucke F, Graumann P, Koch HG. Predominant membrane localization is an essential feature of the bacterial signal recognition particle receptor. BMC Biol. 2009 Nov 13;7:76.  Abstract

Angelini S, Boy D, Schiltz E, Koch HG. Membrane binding of the bacterial signal recognition particle receptor involves two distinct binding sites. J Cell Biol. 2006 Aug 28;174(5):715-24.  Abstract

Angelini S, Deitermann S, Koch HG. FtsY, the bacterial signal-recognition particle receptor, interacts functionally and physically with the SecYEG translocon. EMBO Rep. 2005 May;6(5):476-81.  Abstract

Alami M, Lüke I, Deitermann S, Eisner G, Koch HG, Brunner J, Müller M. Differential interactions between a twin-arginine signal peptide and its translocase in Escherichia coli. Mol Cell. 2003 Oct;12(4):937-46.  Abstract

Neumann-Haefelin C, Schäfer U, Müller M, Koch HG. SRP-dependent co-translational targeting and SecA-dependent translocation analyzed as individual steps in the export of a bacterial protein. EMBO J. 2000 Dec 1;19(23):6419-26.  Abstract

SGBM PhD students

SGBM PhD students:


Track 2:

Andreas Vogt (08/2011 - 10/2015)

Renuka Kudva (01/2009 - 08/2013)

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