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Hans-Georg Koch Profile Page
Hans-Georg Koch


Lab: Prof. Dr. Hans-Georg Koch
Department: Institute of Biochemistry and Molecular Biology
Address: Stefan-Meier-Str. 17
Phone: 0049 761 203 5250
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
PhD positions available: YES
Research Area: Protein Structure and Function
Research Interests: Targeting, integration and assembly of bacterial membrane proteins


Education & Training: 1985-87 Pre-Diploma in Biology, Göttingen University
1987-91 Diploma in Biology, Bonn University
1994 Dr.rer.nat. in Microbiology, Bonn University
2002 Habilitation in Biochemistry, Freiburg University
Employment & Experience: 1992 Visiting Research Fellow in Biochemistry, University of Cordoba, Spain
1994-1997 Post-Doctoral Researcher, University of Pennsylvania, Philadelphia, USA
1997-2002 Post-Doc in Biochemistry, Albert-Ludwigs-University Freiburg, Germany
2002-present Group Leader, Albert-Ludwigs-University Freiburg, Germany
Scientific Activities: 1990-present Member, German Association of General and Applied Microbiology
1996-1997 Scientific Advisor, Lew-Tilney Fellowship Program, University of Pennsylvania,
Philadelphia, USA
2000-2006 Member, Selection Committee Studienstiftung des Deutschen Volkes
2000-present ad hoc Reviewer for scientific journals (e.g. EMBO J., Mol. Microbiol., J. Cell
2002-present Reviewer for the ‚Agence Nationale de la Recherche’ France; National
Science Foundation USA’; ‘Deutsche Forschungsgemeinschaft’; ‘Israel
Science Foundation’ and ‘Netherlands Organisation for Scientific Research
2003-present Member, Editorial Committee ‘Biochemistry’, Foxwell & Davies Publishers
2004-present Member Mentoring Program University Freiburg Medical School


Honors and Awards:

1992 Research Fellowship, Gesellschaft f. Biotechnologische Forschung
1993-1994 PhD Fellowship, Studienstiftung des Deutschen Volkes
1994-1997 Post-Doctoral Fellowship, National Institute of Health, USA
1997 Young Scientist Award, Internat. Society for Photosynthesis
1997 Young Scientist Grant, Fed. Europ. Microbiol. Societies (FEMS)
2004-2006 Member of the Collaborative Research Centre 388
since 2007 Member German-French PhD College on Membranes and Membrane Proteins
since 2008 Member International Graduate School on Membranes and Membrane
Proteins (DFG-GRK1478)
since 2008 Member Research Group on Ribosomal Exit Tunnel Ligands (DFG-FOR967)
since 2008 Member Research Group on Bacterial Membrane Protein Dynamics (DFGFOR929)


Selected Publications:

Steinberg R, Koch HG. The largely unexplored biology of small proteins in pro- and eukaryotes. FEBS J. 2021 Dec;288(24):7002-7024. Abstract

Landwehr V, Milanov M, Angebauer L, Hong J, Jüngert G, Hiersemenzel A, Siebler A, Schmit F, Öztürk Y, Dannenmaier S, Drepper F, Warscheid B, Koch HG. The Universally Conserved ATPase YchF Regulates Translation of Leaderless mRNA in Response to Stress Conditions. Front Mol Biosci. 2021 May 7;8:643696. Abstract

Wang X, Bittner T, Milanov M, Kaul L, Mundinger S, Koch HG, Jessen-Trefzer C, Jessen HJ. Pyridinium Modified Anthracenes and Their Endoperoxides Provide a Tunable Scaffold with Activity against Gram-Positive and Gram-Negative Bacteria. ACS Infect Dis. 2021 Aug 13;7(8):2073-2080. Abstract

Steinberg R, Origi A, Natriashvili A, Sarmah P, Licheva M, Walker PM, Kraft C, High S, Luirink J, Shi WQ, Helmstädter M, Ulbrich MH, Koch HG. Posttranslational insertion of small membrane proteins by the bacterial signal recognition particle. PLoS Biol. 2020 Sep 30;18(9):e3000874. Abstract

Jauss B, Petriman NA, Drepper F, Franz L, Sachelaru I, Welte T, Steinberg R, Warscheid B, Koch HG. Noncompetitive binding of PpiD and YidC to the SecYEG translocon expands the global view on the SecYEG interactome in Escherichia coli. J Biol Chem. 2019 Dec 13;294(50):19167-19183. Abstract

Marckmann D, Trasnea PI, Schimpf J, Winterstein C, Andrei A, Schmollinger S, Blaby-Haas CE, Friedrich T, Daldal F, Koch HG. The cbb3-type cytochrome oxidase assembly factor CcoG is a widely distributed cupric reductase. Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21166-21175.  Abstract

Denks K, Sliwinski N, Erichsen V, Borodkina B, Origi A, Koch HG. The signal recognition particle contacts uL23 and scans substrate translation inside the ribosomal tunnel. Nat Microbiol. 2017 Jan 30;2:16265.  Abstract

Kuhn P, Draycheva A, Vogt A, Petriman NA, Sturm L, Drepper F, Warscheid B, Wintermeyer W, Koch HG. Ribosome binding induces repositioning of the signal recognition particle receptor on the translocon. J Cell Biol. 2015 Oct 12;211(1):91-104. Abstract

Angelini S, Deitermann S, Koch HG. FtsY, the bacterial signal-recognition particle receptor, interacts functionally and physically with the SecYEG translocon. EMBO Rep. 2005 May;6(5):476-81.  Abstract

Neumann-Haefelin C, Schäfer U, Müller M, Koch HG. SRP-dependent co-translational targeting and SecA-dependent translocation analyzed as individual steps in the export of a bacterial protein. EMBO J. 2000 Dec 1;19(23):6419-26. Abstract

SGBM PhD students

SGBM PhD students:

Hong Jiang (since August 2020)

Martin Milanov (March 2020)



Andreas Vogt (08/2011 - 10/2015)

Renuka Kudva (01/2009 - 08/2013)

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