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Contact
| Lab: | Prof. Dr. Hans-Georg Koch |
| Department: | Institute of Biochemistry and Molecular Biology |
| Address: | Stefan-Meier-Str. 17 |
| Phone: | 0049 761 203 5250 |
| E-mail: | This e-mail address is being protected from spambots. You need JavaScript enabled to view it |
| Lab homepage: | www.biochemie.uni-freiburg.de/ag/koch |
| PhD positions available: | YES |
| Research Area: | Protein Structure and Function |
| Research Interests: | Targeting, integration and assembly of bacterial membrane proteins |
CV
| Education & Training: | 1985-87 Pre-Diploma in Biology, Göttingen University 1987-91 Diploma in Biology, Bonn University 1994 Dr.rer.nat. in Microbiology, Bonn University 2002 Habilitation in Biochemistry, Freiburg University |
| Employment & Experience: | 1992 Visiting Research Fellow in Biochemistry, University of Cordoba, Spain 1994-1997 Post-Doctoral Researcher, University of Pennsylvania, Philadelphia, USA 1997-2002 Post-Doc in Biochemistry, Albert-Ludwigs-University Freiburg, Germany 2002-present Group Leader, Albert-Ludwigs-University Freiburg, Germany |
| Scientific Activities: | 1990-present Member, German Association of General and Applied Microbiology (VAAM) 1996-1997 Scientific Advisor, Lew-Tilney Fellowship Program, University of Pennsylvania, Philadelphia, USA 2000-2006 Member, Selection Committee Studienstiftung des Deutschen Volkes 2000-present ad hoc Reviewer for scientific journals (e.g. EMBO J., Mol. Microbiol., J. Cell Biol.) 2002-present Reviewer for the ‚Agence Nationale de la Recherche’ France; National Science Foundation USA’; ‘Deutsche Forschungsgemeinschaft’; ‘Israel Science Foundation’ and ‘Netherlands Organisation for Scientific Research (NWO)’ 2003-present Member, Editorial Committee ‘Biochemistry’, Foxwell & Davies Publishers 2004-present Member Mentoring Program University Freiburg Medical School |
Honors
| Honors and Awards: | 1992 Research Fellowship, Gesellschaft f. Biotechnologische Forschung |
Publications
| Selected Publications: | Denks K, Sliwinski N, Erichsen V, Borodkina B, Origi A, Koch HG. The signal recognition particle contacts uL23 and scans substrate translation inside the ribosomal tunnel. Nat Microbiol. 2017 Jan 30;2:16265. Abstract Braig D, Nero TL, Koch HG, Kaiser B, Wang X, Thiele JR, Morton CJ, Zeller J, Kiefer J, Potempa LA, Mellett NA, Miles LA, Du XJ, Meikle PJ, Huber-Lang M, Stark GB, Parker MW, Peter K, Eisenhardt SU. Transitional changes in the CRP structure lead to the exposure of proinflammatory binding sites. Nat Commun. 2017 Jan 23;8:14188. Abstract Kuhn P, Draycheva A, Vogt A, Petriman NA, Sturm L, Drepper F, Warscheid B, Wintermeyer W, Koch HG. Ribosome binding induces repositioning of the signal recognition particle receptor on the translocon. J Cell Biol. 2015 Oct 12;211(1):91-104. Abstract Hannemann L, Suppanz I, Ba Q, MacInnes K, Drepper F, Warscheid B, Koch HG. Redox Activation of the Universally Conserved ATPase YchF by Thioredoxin 1. Antioxid Redox Signal. 2016 Jan 20;24(3):141-56. Abstract Welte T, Kudva R, Kuhn P, Sturm L, Braig D, Müller M, Warscheid B, Drepper F, Koch HG. Promiscuous targeting of polytopic membrane proteins to SecYEG or YidC by the Escherichia coli signal recognition particle. Mol Biol Cell. 2012 Feb;23(3):464-79. Abstract Mircheva M, Boy D, Weiche B, Hucke F, Graumann P, Koch HG. Predominant membrane localization is an essential feature of the bacterial signal recognition particle receptor. BMC Biol. 2009 Nov 13;7:76. Abstract Angelini S, Boy D, Schiltz E, Koch HG. Membrane binding of the bacterial signal recognition particle receptor involves two distinct binding sites. J Cell Biol. 2006 Aug 28;174(5):715-24. Abstract Angelini S, Deitermann S, Koch HG. FtsY, the bacterial signal-recognition particle receptor, interacts functionally and physically with the SecYEG translocon. EMBO Rep. 2005 May;6(5):476-81. Abstract Alami M, Lüke I, Deitermann S, Eisner G, Koch HG, Brunner J, Müller M. Differential interactions between a twin-arginine signal peptide and its translocase in Escherichia coli. Mol Cell. 2003 Oct;12(4):937-46. Abstract Neumann-Haefelin C, Schäfer U, Müller M, Koch HG. SRP-dependent co-translational targeting and SecA-dependent translocation analyzed as individual steps in the export of a bacterial protein. EMBO J. 2000 Dec 1;19(23):6419-26. Abstract |
SGBM PhD students
| SGBM PhD students: | Alumni Track 2: Andreas Vogt (08/2011 - 10/2015) Renuka Kudva (01/2009 - 08/2013) |
