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Oliver Schilling Profile Page
Oliver Schilling


Lab: Prof. Dr. Oliver Schilling
Department: Heisenberg Professor of Translational Proteomics,
Institute of Surgical Pathology, Faculty of Medicine, University of Freiburg
Address: Breisacher Strasse 115a
D-79106 Freiburg
Phone: +49 761 27080610
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
PhD positions available: YES
Research Area: Molecular Medicine
Research Interests: We apply innovative proteomic and degradomic techniques to understand how proteolysis contributes to physiological and pathological processes. With over 560 proteases in man, this enzyme family ranks among the most abundant protein classes, illustrating its ubiquitous importance in human biology. We understand proteolysis as a post-translational modification that regulates protein location, function, and abundance.


Education & Training: 2000 Diploma in Biology at Muenster University
2004 - Dr.rer.nat. in Biology at Muenster University, Germany &
European Molecular Biology Laboratory
Employment & Experience: 2005-2008 Postdoctoral fellow
Centre for Blood Research,
University of British Columbia, Vancouver, Canada
2008-present Junior group leader
Institute for Molecular Medicine and Cell Research,
Albert-Ludwigs-University Freiburg
Since 2009 part of the DFG Emmy-Noether Program
Scientific Activities: Since 2009 ad hoc referee for scientific journals (Biol. Chem., Chem. & Biol.,
Expert Rev. Proteomic., Mol. Cell. Proteomics, Nat. Protocols)


Honors and Awards:

2005 PhD Thesis Award of Deutsches Elektronen Synchrotron, Hamburg
2005-2008 Postdoctoral fellowship of the Michael Smith Foundation,
Vancouver, Canada
2006-2008 DFG postdoctoral fellowship
2009-present Emmy-Noether fellowship of DFG for “Substrate Profiling of Cysteine
Protease in Physiology and Pathology”


Selected Publications:

Küttner V, Mack C, Rigbolt KT, Kern JS, Schilling O, Busch H, Bruckner-Tuderman L, Dengjel J. Global remodelling of cellular microenvironment due to loss of collagen VII.
Molecular Systems Biology. Apr 16;9:657. (2013) Abstract

Tholen S, Biniossek ML, Gansz M, Gomez-Auli A, Werner F, Noel A, Kizhakkedathu JN, Boerries M, Busch H, Reinheckel T, Schilling O. Deletion of Cysteine Cathepsins B or L Yields Differential Impacts on Murine Skin Proteome and Degradome.
Molecular & Cellular Proteomics, 12(3):611-25. (2013) Abstract

Biniossek ML, Schilling O. Enhanced Identification of Peptides Lacking Basic Residues by Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometric Analysis of Singly Charged Peptides. Proteomics, 9, 1303-9 (2012) Abstract

Perera NC, Schilling O, Kittel H, Back W, Kremmer E, Jenne DE. NSP4, a Novel Elastase-related Protease in Human Neutrophils With Arginine Specificity. Proceedings of the National Academy of Sciences of the United States of America, 109, 6229-6234. (2012) Abstract

Tholen S, Biniossek ML, Gessler AL, Muller S, Weisser J, Kizhakkedathu JN, Reinheckel T, Schilling O. Contribution of Cathepsin L to Secretome Composition and Cleavage Pattern of Mouse Embryonic Fibroblasts. Biological Chemistry, 392, 961-71. (2011) Abstract

Biniossek ML, Nagler DK, Becker-Pauly C, Schilling O. Proteomic Identification of Protease Cleavage Sites Characterizes Prime and Non-prime Specificity of Cysteine Cathepsins B, L, and S. Journal of Proteome Research, 10, 5363-373. (2011) Abstract

Schilling O, auf dem Keller U, Overall CM. Factor Xa Subsite Mapping by Proteome-derived Peptide Libraries Improved Using Webpics, a Resource for Proteomic Identification of Cleavage Sites. Biological Chemistry, 392, 1031-37. (2011) Abstract

Becker-Pauly C, Barre O, Schilling O, auf dem Keller U, Ohler A, Broder C, Schutte A, Kappelhoff R, Stocker W, Overall, CM. Proteomic Analyses Reveal an Acidic Prime Side Specificity for the Astacin Metalloprotease Family Reflected by Physiological Substrates. Molecular & Cellular Proteomics, 10, M111 009233. (2011) Abstract

Jefferson T, Causevic M, auf dem Keller U, Schilling O, Isbert S, Geyer R, Maier W, Tschickardt S, Jumpertz T, Weggen S, Bond J, Overall CM, Pietrzik CU, Becker-Pauly C. Metalloprotease Meprin-beta Generates Nontoxic N-terminal Amyloid Precursor Protein Fragments in Vivo. Journal of Biological Chemistry, 286, 27741-50. (2011) Abstract

Schilling O, Barré O, Huesgen PF, Overall CM. Proteome-Wide Analysis of Protein Carboxy Termini: C Terminomics. Nature Methods, 7, 508-11. (2010) Abstract

SGBM PhD students

SGBM PhD students:

Track 2:

Patrick Bernhard (since December 2019)

Tilman Werner (since August 2019)

Matthias Fahrner (since May 2017)

Klemens Fröhlich (since April 2017)



Victor Oria (Jan 2015-Nov 2018)

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