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Robert Zeiser Profile Page
Robert Zeiser

Contact

Lab: Prof. Dr. Robert Zeiser
Department: Department of Hematology and Oncology
University Medical Center Freiburg
Address: Hugstetter Str. 55
79106 Freiburg
Phone: +49 761 270 36250
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage: www.uniklinik-freiburg.de/medizin1/forschung/experimentelle-forschung/allo-immunregulation.html
PhD positions available: YES
Research Area: Immunology and Virology
Research Interests: Cellular Immunology, Transplantation Immunology, Molecular Imaging

CV

Education & Training: 2010 Habilitation: Internal Medicine, University of Freiburg
2001 Promotion: Medicine, University of Freiburg
1995 – 2001 Medical studies at Freiburg University

Employment & Experience: since 2013 W3 Heisenberg Professorship
since 2010 Consultant physician, Dept. of Hematology and Oncology, Freiburg
2011 Heisenberg Stipend
2007-2010 Assistant physician, Dept. of Hematology and Oncology, Freiburg
2005-2007 Postdoctorate, Stanford University School of Medicine, BMT Department, USA
2001-2004 Internship in Internal Medicine, Dept. of Hematology and Oncology, Freiburg
Scientific Activities: Since 2013 Collaborative Research Centre 850 Board member

Honors

Honors and Awards:

2015     Jon J. van Rood Award (European Society for Blood and Marrow Transplantation, EBMT, Istanbul)
2014     Artur Pappenheim Award (German Society of Hematology and Oncology (DGHO) Conference, Hamburg)
03/2014    Hans-Jochem Kolb Research Award 2014 (Univ. Regensburg)
02/2014    Karin Nolte Research Award 2014 (SPIG)
06/2012    Science Award 2012 of the German BMT working group (DAG-KBT)
05/2011    Theodor Frerichs-Award (Deutschen Gesellschaft für Innere Medizin)
10/2008    Eugen Graetz-Preis 2008 für translationale Forschung, Freiburg
02/2008    BBMT Editorial Award: Best basic science article of 2007
09/2007    Best Abstract Award, XXIII Symposium of the IACRLRD
12/2006    American Society of Hematology Scholar Award
04/2006    Trainee Research Award, American Society of Hematology 2006

 

Publications

Selected Publications:

Klämbt V, Wohlfeil SA, Schwab L, Hülsdünker J, Ayata K, Apostolova P, Schmitt-Graeff A, Dierbach H, Prinz G, Follo M, Prinz M, Idzko M, Zeiser R. A Novel Function for P2Y2 in Myeloid Recipient-Derived Cells during Graft-versus-Host Disease. J Immunol. 195: 5795-804, 2015. Abstract

Zeiser R, Burchert A, Lengerke C, Verbeek M, Maas-Bauer K, Metzelder SK, Spoerl S, Ditschkowski M, Ecsedi M, Sockel K, Ayuk F, Ajib S, de Fontbrune FS, Na IK, Penter L, Holtick U, Wolf D, Schuler E, Meyer E, Apostolova P, Bertz H, Marks R, Lübbert M, Wäsch R, Scheid C, Stölzel F, Ordemann R, Bug G, Kobbe G, Negrin R, Brune M, Spyridonidis A, Schmitt-Gräff A, van der Velden W, Huls G, Mielke S, Grigoleit GU, Kuball J, Flynn R, Ihorst G, Du J, Blazar BR, Arnold R, Kröger N, Passweg J, Halter J, Socié G, Beelen D, Peschel C, Neubauer A, Finke J, Duyster J, von Bubnoff N. Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation:  a multi-center survey. Leukemia 29: 2062-8, 2015. Abstract

Chen S, Smith BA, Iype J, Prestipino A, Pfeifer D, Grundmann S, Schmitt-Graeff A, Idzko M, Beck Y, Prinz G, Finke J, Duyster J, Zeiser R. MicroRNA-155 deficient dendritic cells cause less severe GvHD through reduced migration and defective inflammasome activation. Blood 126: 103-12, 2015. Abstract

Hechinger AK, Smith BA, Flynn R, Hanke K, McDonald-Hyman C, Taylor PA, Pfeifer D, Hackanson B, Leonhardt F, Prinz G, Dierbach H, Schmitt-Graeff A, Kovarik J, Blazar BR, Zeiser R. Therapeutic activity of multiple common gamma chain cytokine inhibition in acute and chronic GvHD. Blood 125:570-80, 2015. Highlighted in Pérez-Simón JA. Blood 125: 424-6. 2015. Abstract

Schwab, L, Goroncy, L, Palaniyandi, S., Gautam, S., Triantafyllopoulou, A., Mocsai, A, Reichardt, W., Karlsson, FJ, Radhakrishnan, SV, Hanke, K, Schmitt-Graeff, ., Freudenberg, M, von Loewenich, FD, Wolf, P, Leonhardt, F, Baxan, N, Pfeifer, D, Schmah, O, Schönle, A, Martin, SF, Mertelsmann, R, Duyster, J, Finke, J., Prinz, M., Henneke, P., Häcker, H., Hildebrandt, G.C, Häcker, G, Zeiser, R. Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance GvHD via tissue damage. Nature Medicine  20: 648-54, 2014. Highlighted in Kugelberg E. Nature Reviews Immunology, 2014. Abstract

Yaktapour N, Meiss F, Mastroianni J, Zenz T, Andrlova H, Mathew NR, Claus R, Hutter B, Fröhling S, Brors B, Pfeifer D, Pantic M, Bartsch I, Spehl TS, Meyer PT, Duyster J, Zirlik K, Brummer T, Zeiser R. BRAF inhibitor-associated ERK activation drives development of chronic lymphocytic leukemia. J Clin Invest. 124: 5074-84, 2014  Highlighted in Wu C.J. J Clin Invest. 124:4681-3, 2014. Abstract

Haug S, Schnerch D, Halbach S, Mastroianni J, Dumit VI, Follo M, Hasenburg A, Köhler M, Dierbach H, Herzog S, Proske A, Werner M, Dengjel J, Brummer T, Laßmann S, Wäsch R, Zeiser R. Metadherin exon 11 skipping variant enhances metastatic spread of ovarian cancer. Int J Cancer , early online 2014. Abstract

Stickel N, Prinz G, Pfeifer D, Hasselblatt P, Schmitt-Graeff A, Follo M, Thimme R, Finke J, Duyster J, Salzer U, Zeiser R. MiR-146a regulates the TRAF6/TNF-axis in donor T cells during GvHD. Blood 124: 2586-95, 2014. Abstract

Jankovic D, Ganesan J, Bscheider M, Stickel N, Weber F, Guarda G, Follo M, Pfeifer D, Tardivel A, Ludigs K, Bouazzaoui A, Kerl K, Fischer J, Haas T, Schmitt-Gräff A, Manoharan A, Müller L, Finke J, Martin S, Gorka O, Peschel C, Ruland J, Idzko M, Duyster J, Holler E, French LE, Poeck H*, Contassot E, Zeiser R. The Nlrp3-inflammasome regulates acute graft-versus-host disease. J Exp Med 210:1899-910, 2013. Abstract

Leonhardt F, Grundmann S, Behe M, Bluhm F, Dumont, RA, Braun F, Melpomeni F, Riesner K, Prinz G, Hechinger AK, Gerlach UV, Dierbach H, Penack O, Schmitt-Gräff A, Finke J, Weber WA, Zeiser R. Inflammatory neovascularization during graft-versus-host disease is regulated by αv integrin and miR-100. Blood 121:3307-3318, 2013 Highlighted in Komanduri KV et al. Blood 121:3303-4, 2014. Abstract

Leonhardt F. Zirlik K, Buchner M, Prinz G, Hechinger AK, Gerlach UV, Fisch P, Schmitt-Gräff A, Reichardt W, Zeiser R. Spleen tyrosine kinase (Syk) is a potent target for GvHD prevention at different cellular levels. Leukemia 26: 1617-1629, 2012. Abstract

Wilhelm, K, Ganesan J, Müller T, Dürr C, Grimm, M, Beilhack, A, Krempl, CD, Sorichter, S, Gerlach, UV, Jüttner, E, Zerweck, A, Gärtner, F, Pellegatti, P, Di Virgilio, F, Ferrari, D, Kambham, N, Fisch, P, Finke, J, Idzko, M, Zeiser, R. Graft-versus-host disease is enhanced by extracellular adenosine triphosphate activating P2X7R. Nature Medicine 12: 1434-1438, 2010. Abstract

Dürr, C, Pfeifer, D, Claus, R, Schmitt-Graeff, A, Gerlach, UV, Graeser, R, Krüger, S, Gerbitz, A, Negrin, RS, Finke, J, Zeiser R. CXCL12 mediates immunosuppression in the lymphoma microenvironment after allogeneic transplantation of hematopoietic cells. Cancer Research 70: 10170-10181, 2010. Abstract

SGBM PhD students

SGBM PhD students:

 

Alumni

Track 1:
Natalie Stickel
(04/2012 - 09/2015)

Track 1:
Jan Hülsdünker (01/2014 - 06/2018)

 

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