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Contact
Lab: | Prof. Dr. Robert Zeiser |
Department: | Department of Hematology and Oncology University Medical Center Freiburg |
Address: | Hugstetter Str. 55 79106 Freiburg |
Phone: | +49 761 270 36250 |
E-mail: | This e-mail address is being protected from spambots. You need JavaScript enabled to view it |
Lab homepage: | www.uniklinik-freiburg.de/medizin1/forschung/experimentelle-forschung/allo-immunregulation.html |
PhD positions available: | YES |
Research Area: | Immunology and Virology |
Research Interests: | Cellular Immunology, Transplantation Immunology, Molecular Imaging |
CV
Education & Training: | 2010 Habilitation: Internal Medicine, University of Freiburg 2001 Promotion: Medicine, University of Freiburg 1995 – 2001 Medical studies at Freiburg University |
Employment & Experience: | since 2013 W3 Heisenberg Professorship since 2010 Consultant physician, Dept. of Hematology and Oncology, Freiburg 2011 Heisenberg Stipend 2007-2010 Assistant physician, Dept. of Hematology and Oncology, Freiburg 2005-2007 Postdoctorate, Stanford University School of Medicine, BMT Department, USA 2001-2004 Internship in Internal Medicine, Dept. of Hematology and Oncology, Freiburg |
Scientific Activities: | Since 2013 Collaborative Research Centre 850 Board member |
Honors
Honors and Awards: | 2015 Jon J. van Rood Award (European Society for Blood and Marrow Transplantation, EBMT, Istanbul)
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Publications
Selected Publications: | Klämbt V, Wohlfeil SA, Schwab L, Hülsdünker J, Ayata K, Apostolova P, Schmitt-Graeff A, Dierbach H, Prinz G, Follo M, Prinz M, Idzko M, Zeiser R. A Novel Function for P2Y2 in Myeloid Recipient-Derived Cells during Graft-versus-Host Disease. J Immunol. 195: 5795-804, 2015. Abstract Zeiser R, Burchert A, Lengerke C, Verbeek M, Maas-Bauer K, Metzelder SK, Spoerl S, Ditschkowski M, Ecsedi M, Sockel K, Ayuk F, Ajib S, de Fontbrune FS, Na IK, Penter L, Holtick U, Wolf D, Schuler E, Meyer E, Apostolova P, Bertz H, Marks R, Lübbert M, Wäsch R, Scheid C, Stölzel F, Ordemann R, Bug G, Kobbe G, Negrin R, Brune M, Spyridonidis A, Schmitt-Gräff A, van der Velden W, Huls G, Mielke S, Grigoleit GU, Kuball J, Flynn R, Ihorst G, Du J, Blazar BR, Arnold R, Kröger N, Passweg J, Halter J, Socié G, Beelen D, Peschel C, Neubauer A, Finke J, Duyster J, von Bubnoff N. Ruxolitinib in corticosteroid-refractory graft-versus-host disease after allogeneic stem cell transplantation: a multi-center survey. Leukemia 29: 2062-8, 2015. Abstract Chen S, Smith BA, Iype J, Prestipino A, Pfeifer D, Grundmann S, Schmitt-Graeff A, Idzko M, Beck Y, Prinz G, Finke J, Duyster J, Zeiser R. MicroRNA-155 deficient dendritic cells cause less severe GvHD through reduced migration and defective inflammasome activation. Blood 126: 103-12, 2015. Abstract Hechinger AK, Smith BA, Flynn R, Hanke K, McDonald-Hyman C, Taylor PA, Pfeifer D, Hackanson B, Leonhardt F, Prinz G, Dierbach H, Schmitt-Graeff A, Kovarik J, Blazar BR, Zeiser R. Therapeutic activity of multiple common gamma chain cytokine inhibition in acute and chronic GvHD. Blood 125:570-80, 2015. Highlighted in Pérez-Simón JA. Blood 125: 424-6. 2015. Abstract Schwab, L, Goroncy, L, Palaniyandi, S., Gautam, S., Triantafyllopoulou, A., Mocsai, A, Reichardt, W., Karlsson, FJ, Radhakrishnan, SV, Hanke, K, Schmitt-Graeff, ., Freudenberg, M, von Loewenich, FD, Wolf, P, Leonhardt, F, Baxan, N, Pfeifer, D, Schmah, O, Schönle, A, Martin, SF, Mertelsmann, R, Duyster, J, Finke, J., Prinz, M., Henneke, P., Häcker, H., Hildebrandt, G.C, Häcker, G, Zeiser, R. Neutrophil granulocytes recruited upon translocation of intestinal bacteria enhance GvHD via tissue damage. Nature Medicine 20: 648-54, 2014. Highlighted in Kugelberg E. Nature Reviews Immunology, 2014. Abstract Yaktapour N, Meiss F, Mastroianni J, Zenz T, Andrlova H, Mathew NR, Claus R, Hutter B, Fröhling S, Brors B, Pfeifer D, Pantic M, Bartsch I, Spehl TS, Meyer PT, Duyster J, Zirlik K, Brummer T, Zeiser R. BRAF inhibitor-associated ERK activation drives development of chronic lymphocytic leukemia. J Clin Invest. 124: 5074-84, 2014 Highlighted in Wu C.J. J Clin Invest. 124:4681-3, 2014. Abstract Haug S, Schnerch D, Halbach S, Mastroianni J, Dumit VI, Follo M, Hasenburg A, Köhler M, Dierbach H, Herzog S, Proske A, Werner M, Dengjel J, Brummer T, Laßmann S, Wäsch R, Zeiser R. Metadherin exon 11 skipping variant enhances metastatic spread of ovarian cancer. Int J Cancer , early online 2014. Abstract Stickel N, Prinz G, Pfeifer D, Hasselblatt P, Schmitt-Graeff A, Follo M, Thimme R, Finke J, Duyster J, Salzer U, Zeiser R. MiR-146a regulates the TRAF6/TNF-axis in donor T cells during GvHD. Blood 124: 2586-95, 2014. Abstract Jankovic D, Ganesan J, Bscheider M, Stickel N, Weber F, Guarda G, Follo M, Pfeifer D, Tardivel A, Ludigs K, Bouazzaoui A, Kerl K, Fischer J, Haas T, Schmitt-Gräff A, Manoharan A, Müller L, Finke J, Martin S, Gorka O, Peschel C, Ruland J, Idzko M, Duyster J, Holler E, French LE, Poeck H*, Contassot E, Zeiser R. The Nlrp3-inflammasome regulates acute graft-versus-host disease. J Exp Med 210:1899-910, 2013. Abstract Leonhardt F, Grundmann S, Behe M, Bluhm F, Dumont, RA, Braun F, Melpomeni F, Riesner K, Prinz G, Hechinger AK, Gerlach UV, Dierbach H, Penack O, Schmitt-Gräff A, Finke J, Weber WA, Zeiser R. Inflammatory neovascularization during graft-versus-host disease is regulated by αv integrin and miR-100. Blood 121:3307-3318, 2013 Highlighted in Komanduri KV et al. Blood 121:3303-4, 2014. Abstract Leonhardt F. Zirlik K, Buchner M, Prinz G, Hechinger AK, Gerlach UV, Fisch P, Schmitt-Gräff A, Reichardt W, Zeiser R. Spleen tyrosine kinase (Syk) is a potent target for GvHD prevention at different cellular levels. Leukemia 26: 1617-1629, 2012. Abstract Wilhelm, K, Ganesan J, Müller T, Dürr C, Grimm, M, Beilhack, A, Krempl, CD, Sorichter, S, Gerlach, UV, Jüttner, E, Zerweck, A, Gärtner, F, Pellegatti, P, Di Virgilio, F, Ferrari, D, Kambham, N, Fisch, P, Finke, J, Idzko, M, Zeiser, R. Graft-versus-host disease is enhanced by extracellular adenosine triphosphate activating P2X7R. Nature Medicine 12: 1434-1438, 2010. Abstract Dürr, C, Pfeifer, D, Claus, R, Schmitt-Graeff, A, Gerlach, UV, Graeser, R, Krüger, S, Gerbitz, A, Negrin, RS, Finke, J, Zeiser R. CXCL12 mediates immunosuppression in the lymphoma microenvironment after allogeneic transplantation of hematopoietic cells. Cancer Research 70: 10170-10181, 2010. Abstract |
SGBM PhD students
SGBM PhD students: | Verena Holzmüller (as of November 2022)
Alumni
Jan Hülsdünker (01/2014 - 06/2018)
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