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Frank Edlich Profile Page
Frank Edlich

Contact

Lab: Dr. Frank Edlich
Department: Emmy Noether research group leader
Institute of Biochemistry and Molecular Biology
Phone: 203-97482
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage: www.biochemie.uni-freiburg.de/ag/edlich
PhD positions available: YES
Research Area: Protein Structure and Function
Research Interests: Regulation of Bcl-2 proteins by conformational changes in healthy and apoptotic cells

CV

Education & Training: 1997 - 2002 Diploma in Biopchemistry at Martin-Luther-University Halle, Germany
2000 - 2001 BSc in Biochemistry at University of Leeds, UK
2002 - 2006 Dr.rer.nat. in Biochemistry at MPI „Enzymology of Protein Folding“ Halle, Germany
Employment & Experience: 2006-2007 Postdoctoral Research, Max Planck research unit „Enzymology of Protein Folding“ in Halle/Saale, Germany
2008-2011 Postdoctoral Research, Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke (NINDS), Institutes of Health (NIH), Bethesda, MD, USA
since 06/2011 Emmy Noether research group leader, Institute for Biochemistry and Molecularbiology, Albert-Ludwigs-University Freiburg, Germany
Scientific Activities: Since 2010 ad hoc referee for scientific journals (Cell Death Diff.)

Honors

Honors and Awards:

10/2012 Pfizer Young researcher award for experimental and clinical cancer research
since 05/2011 Emmy Noether fellowship
01/2008-12/2010 Post-Doctoral fellowship of the German National Academy of Sciences, Leopoldina
06/2006 Martin Luther award for excellent dissertation

Publications

Selected Publications:

Todt F., Cakir Z., Reichenbach F., Emschermann F., Lauterwasser J., Kaiser A., Ichim G., Tait S.W.G., Frank S., Langer H.F. and Edlich F. (2015). Differential retrotranslocation of mitochondrial Bax and Bak. EMBO J., 34, 67-80. Abstract

Todt, F., Cakir, Z., Reichenbach, F., Youle, R.J., Edlich, F. (2013) The C-terminal helix of Bcl-x(L) mediates Bax retrotranslocation from the mitochondria. Cell Death Differ, 20, 333-42. Abstract

Ma, J., Edlich, F., Bermejo, G.A., Norris, K.L., Youle, R.J., Tjandra, N. (2012) Structural Mechanism of Bax Inhibition by Cytomegalovirus Protein vMIA. Proc Natl Acad Sci USA, 109, 20901-6. Abstract

Haupt, K., Jahreis, G., Linnert, M., Maestre-Martinez, M., Malesevic, M., Pechstein, A., Edlich, F., Lücke, C. (2012). The Catalytic Domain of FKBP38 Binds to Bcl-2 via a Charge-sensitive Loop. J Biol Chem 287, 19665-73. Abstract

Edlich, F., Banerjee, S., Suzuki, M., Cleland, M.M., Arnoult, D., Wang, C., Neutzner, A., Tjandra, N., Youle, R.J. (2011) Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol. Cell 145, 104-16. Abstract

Hoppins, S., Edlich, F., Cleland, M.M., Banerjee, S., McCaffery, J.M., Youle, R.J., Nunnari, J. (2011) The soluble form of Bax regulates mitochondrial fusion via MFN2 homotypic complexes. Mol Cell 41, 150-60. Abstract

Edlich, F., Lücke, C. (2011). From cell death to viral replication: the diverse functions of the membrane-associated FKBP38. Curr Opin Pharmacol 11, 348-53. Abstract

Barth, S., Edlich, F., Berchner-Pfannschmidt, U., Gneuss, S., Jahreis, G., Hasgall, P.A., Fandrey, J., Wenger, R.H., Camenisch, G. (2009) HIF prolyl-4-hydroxylase PHD2 protein abundance depends on integral membrane-anchoring of FKBP38. J Biol Chem 284, 23046-58. Abstract

Jarczowski, F., Jahreis, G., Erdmann, F., Schierhorn, A., Fischer, G., Edlich, F. (2009). FKBP36 is an inherent multifunctional glyceraldehyde-3-phosphate dehydrogenase inhibitor. J Biol Chem 284, 766-73. Abstract

Jarczowski, F., Fischer G., Edlich, F. (2008). FKBP36 forms complexes with clathrin and Hsp72 in spermatocytes. Biochemistry 47, 6946-6952. Abstract

SGBM PhD students

SGBM PhD students:

Track 1:

Aline Oelgeklaus (since January 2017)

Alumni

Track 2:
Franziska Todt (06/2011 - 03/2015)

Frank Reichenbach (04/2012 - 02/2018)

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