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Contact
Lab: | Prof. Dr. Winfried Römer |
Department: | Institute of Biology II and BIOSS Centre for Biological Signalling Studies |
Address: | Signalhaus Schänzlestraße 18 79104 Freiburg |
Phone: | +49 (0)761 203 67500 |
E-mail: | This e-mail address is being protected from spambots. You need JavaScript enabled to view it |
Lab homepage: | www.bioss.uni-freiburg.de/groups/synthetic-biology-of-signalling-processes/syn-bio-signal-processes/ |
BIOSS Excellence Cluster: | Member |
PhD positions available: | YES |
Research Area: | Synthetic Biology and Signalling |
Research Interests: | Our research is mainly focused on host-pathogen interactions; in particular, we are interested in understanding the impact of bacterial virulence factors on the host cell physiology of single cells, tissues and model organisms in molecular detail by using a combination of analytical and synthetic approaches. For instance, our lab investigates the effects of the P. aeruginosa lectins LecA and LecB on wound healing processes (e.g. cell proliferation, cell adhesion and migration, immune response, cell death). In collaboration with chemists we develop alternative strategies to fight bacterial infections, e.g. glycomimetics that fully block host cell invasion when applied in nano-molar concentrations, or bacteriophages to kill intracellular bacteria. We also design novel CAR-T cell therapy approaches to target and kill cancer cells. |
CV
Education & Training: | 2005-2007: Diploma in Management Consultancy, Akademie für Wirtschaftswissenschaften Bad Harzburg, Germany 2001-2004: Graduate Studies in Chemistry (Dr. rer. nat.), University of Regensburg, Germany 1996-2001: Studies in Biology, Chemistry and Didactics, University of Regensburg, Germany (1st state examination |
Employment & Experience: | Since 2017: Full Professor (W3) for Synthetic Biology of Signalling Processes; Institute of Biology II and BIOSS Centre for Biological Signalling Studies; University of Freiburg, Germany 2011-2017: Junior Professor (W1) for Synthetic Biology of Signalling Processes; Institute of Biology II and BIOSS Centre for Biological Signalling Studies; University of Freiburg, Germany 2008-2017: Permanent Research Scientist (chargé de recherche) at CNRS (French national center for scientific research) and Curie Institute; Traffic, Signaling and Delivery Laboratory; Paris; France 2004-2008: Postdoctoral fellow with Dr. Ludger Johannes at Curie Institute; Traffic, Signaling and Delivery Laboratory; Paris; France |
Scientific Activities: | 2015-2020: Member of the Freiburg Centre for Interactive Materials and Bioinspired Technologies 2014-2018: Elected member of the Advisory Board of the Biology Faculty, University of Freiburg 2013: Organizer of the “Symposium on Advanced Microscopy Techniques in Life Sciences”, Freiburg 2012-2014: Mentoring program for female scientists at the Christian-Albrechts-University Kiel 2012-2014: Membership in the scientific selection panel of the Helmholtz-Zentrum Berlin 2011: Co-organizer of the Congress “Cytoskeleton in membrane trafficking”, Paris 2010-2013: Elected member of the advisory board of the French Society for Cell Biology • Guest Editor for PLOS Computational Biology • Reviewing activity for Nature Communications, Cell Chemical Biology, JACS, Nano Letters, Chemical Science, BBA-Molecular Cell Research, Molecular Biology of the Cell, Cancer Letters, Nature Communications, Biophysical Journal, PLoS ONE, Interface Focus, Biomolecules, Journal of Visualized Experiments (JoVE), for the Landsteiner Foundation for Blood Transfusion Research, the French National Research Agency (ANR), the Medical Research Council (MRC) and EraSynBio (BMBF). • Evaluation activity for HCERES (The High Council for Evaluation of Research and Higher Education, France). |
Honors
Honors and Awards: |
2021: Appointment as FRIAS senior fellow |
Publications
Selected Publications: | Thuenauer R, Landi A, Trefzer A, Altmann S, Wehrum S, Eierhoff T, Diedrich B, Dengjel J, Nyström A, Imberty A, Römer W. The Pseudomonas aeruginosa Lectin LecB Causes Integrin Internalization and Inhibits Epithelial Wound Healing. mBio. 2020 Mar 10;11(2):e03260-19. Abstract |
SGBM PhD students
SGBM PhD students: | Carmen Senin (since July 2021)
Alumni Ana Valeria Melendez Mayorga (01/2018 - 12/2022) Isabel Wilhelm (01/2014 - 01/2018) Samuel Juillot (01/2013 - 08/2016) Anita Nieth (01/2012 - 05/2015) |