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Bettina Warscheid Profile Page
Bettina Warscheid


Lab: Prof. Dr. Bettina Warscheid
Department: BIOSS Centre for Biological Signalling Studies
Institute of Biology II, Faculty of Biology
Address: Schänzlestr. 1
79104 Freiburg
Phone: +49 761 203 2690
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
BIOSS Excellence Cluster: Member
PhD positions available: YES
Research Area: Protein Structure and Function
Research Interests: Proteome biology, proteomics & high-resolution mass spectrometry; cell signaling networks in health and disease; biogenesis of peroxisomes and mitochondria; assembly and functioning of protein-nano machines, protein translocation across membranes.


Education & Training: 1991-1997: Diploma in Chemistry, Technical University Dortmund
1997-2002: PhD in Analytical Chemistry, Institute for Analytical Sciences, Dortmund
Employment & Experience: 2010-present: Full Professor (W3), Biochemistry and Functional Proteomics, Faculty of Biology and Centre for Biological Signalling Studies (BIOSS), University of Freiburg
2009-2010: Professor (W2), Clinical and Cellular Proteomics, Medical Faculty and Centre for Medical Biotechnology, University of Duisburg-Essen
2004-2009: Junior-Professor (W1), Protein Mass Spectrometry, Medical Faculty, Ruhr-University of Bochum (RUB)
2003-2010: Group leader, Cellular Proteomics, Medical Proteome-Centre, RUB
2002-2003: Postdoctoral fellow, University of Maryland, College Park, Maryland, USA
Scientific Activities: 2013: Editor of the book ‘SILAC - Stable Isotope Labeling with Amino Acids in Cell Culture’, Methods in Molecular Biology, Humana Press
2012: US Patent ‘Analyzing and Distinguishing Organisms such as Bacterial Spores by their Soluble Polypeptides’, USPN 10/683,128
2011-2013: Editorial advisory board member of the ‘Journal of Proteome Research’
2011: Co-organizer of the LifeNet conference on ‘Integrative 'Omics' Approaches to Disease Mechanisms’, Freiburg
2011-present: Principal Investigator of the SGBM, University of Freiburg
2010-present: Executive Board member, Excellence Cluster BIOSS, University of Freiburg
2010-present: Member and Assessor at the Board of Directors, Centre for Biological Systems Analysis (ZBSA), University of Freiburg
2007/2008: Organizer of the training course ‘Biological Mass Spectrometry: From Peptides to Proteins and Beyond’, University of Bochum


Honors and Awards:

1996: Undergraduate studies fellowship, German Academic Exchange Program
2002-2003: DFG fellowship for research with Prof. C. Fenselau, University of Maryland, and Prof. R. Cotter, Johns Hopkins University, School of Medicine, Baltimore, MD, USA
2010: Innovative research project award, Structural and Innovation Fond for Research, Ministry of Science, Research and the Arts Baden-Württemberg
2010-present: Core-Professor of the Excellence Cluster BIOSS, University of Freiburg
2014-present: Academic dean of student affairs, Faculty of Biology, University of Freiburg
2015: ERC grant funding


Selected Publications:

Schwarz, J.°, Wiese, H.°, Tölle, R.C., Knapp, B., Warscheid, B.*, Thediek, K.* (2015) Functional proteomics identifies acinus L as a direct insulin- and amino acid-dependent mTORC1 substrate.Mol Cell Proteomics, Apr 23. pii: mcp.M114.045807. **shared senior authorship. Abstract

Mani, J., Desy, S., Niemann, M., Chanfon, A., Oeljeklaus, S., Pusnik, A., Schmidt, O., Meisinger, C., Warscheid, B., Schneider, A. (2015) Mitochondrial protein import receptors in Kinetoplastids reveal convergent evolution over large phylogenetic distances. Nat Commun. 6:6646. Abstract

Wiese, H., Gelis, L., Wiese, S., Reichenbach, C., Jovancevic, N., Osterloh, M., Meyer, H.E., Neuhaus, E.M., Hatt, H., Radziwill, G., Warscheid, B. (2014) Quantitative phosphoproteomics reveals the protein tyrosine kinase Pyk2 as a central effector of olfactory receptor signaling in prostate cancer cells. Biochim Biophys Acta 1854:632-640. Abstract

Kuhlmann, K., Tschapek, A., Wiese, H., Eisenacher, M., Meyer, H.E., Hatt, H., Oeljeklaus, S., Warscheid, B. (2014) The membrane proteome of sensory cilia to the depth of olfactory receptors. Mol Cell Proteomics, 13:1828-1843. Abstract

Wiese, H., Kuhlmann, K., Wiese, S., Stoepel, N.S., Pawlas, M., Meyer, H.E., Stephan, C., Eisenacher, M., Drepper, F., Warscheid, B. (2014) Comparison of alternative MS/MS and bioinformatics approaches for confident phosphorylation site localization. J Proteome Res. 13(2):1128-1137. Abstract

Niemann, M., Wiese, S., Mani, J., Chanfon, A., Jackson, C., Meisinger, C., Warscheid, B.*, Schneider, A.* (2013) Mitochondrial outer membrane proteome of Trypanosoma brucei reveals novel factors required to maintain mitochondrial morphology. Mol Cell Proteomics 12(2):515-528. *shared senior authorship Abstract

David, C., Koch, J-P., Oeljeklaus, S., Laernsack, A., Melchior, S., Wiese, S., Schummer, A., Erdmann, R., Warscheid, B.*, Brocard, C.* (2013) A combined approach of quantitative interaction proteomics and live-cell imaging reveals a regulatory role for ER reticulon homology proteins in peroxisome biogenesis. Mol Cell Proteomics 12(9):2408-2425. *shared senior authorship Abstract

Mick, D.U., Dennerlein, S., Wiese, H., Reinhold, R., Pacheau-Grau, D., Lorenzi, I., Sasarman, F., Weraarpachai, W., Shoubridge, E.A., Warscheid, B., Rehling, P. (2012) MITRAC links mitochondrial protein translocation to respiratory-chain assembly and translational regulation. Cell 151(7):1528-1541. Abstract

Piechura, H., Oeljeklaus, S., Warscheid, B. (2012) SILAC for the study of mammalian cell lines and yeast protein complexes. Methods Mol Biol. 893:201-221. Abstract

Oeljeklaus, S., Reinartz, B.S., Wolf, J., Wiese, S., Tonillo, J., Podwojski, K., Kuhlmann, K., Stephan, C., Meyer, H.E., Schliebs, W., Brocard, C., Erdmann, R., Warscheid, B. (2012) Identification of core components and transient interactors of the peroxisomal importomer by dual-track SILAC analysis. J Proteome Res. 11(4):2567-2580. Abstract

SGBM PhD students

SGBM PhD students:


Jennifer Schwarz (October 2013-October 2018)

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