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Sebastian Arnold Profile Page
Sebastian Arnold

Contact

Lab: Prof. Dr. Sebastian Arnold
Department: Institute for Clinical and Experimental Pharmacology and Toxicology
Department II
Address: Albertstr. 25
79104 Freiburg
Phone: +49 761 203 96819
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage: www.arnold-lab.com
BIOSS Excellence Cluster: Associated member
PhD positions available: YES
Research Area: Developmental Biology
Research Interests: - Signals & transcription factors guiding cell specification during early mouse development
- Generation of differentiated cell types from pluripotent stem cells
- Morphogenesis and cellular mechanisms of germ layer formation

CV

Education & Training: 1994-2001 Medical training at the University of Freiburg
Employment & Experience: since 2016: Group leader, Institute of Pharmacology, University of Freiburg
2017: Heisenberg-Professorship awarded by DFG
2010-2016: Emmy Noether Group Leader, University Medical Centre, Renal Department, Freiburg
2009-2010: Resident and Junior Group Leader, University Medical Centre, Renal Department, Freiburg
2004-2008: Postdoctoral Fellow, laboratory of Prof. E. J. Robertson, Cell and Developmental Biology, University of Oxford, UK
2002-2004: Clinical Resident, University Medical Centre, Renal Department, Freiburg
Scientific Activities: since 2015: Member Executive Board Spemann Graduate School of Biology and Medicine (SGBM), Freiburg
since 2015: Principal Investigator SFB 1140, Freiburg, project B07
since 2014: Member Executive Board SFB 850, Freiburg
since 2011: Member Executive Board Center for Experimental Models and Transgenic Services (CEMT), Freiburg
since 2011: Member Spemann Graduate School of Biology and Medicine (SGBM), Freiburg
since 2011: Associated Member BIOSS, Centre for Biological Signalling Studies, Freiburg
since 2010: Principal Investigator SFB 850, Freiburg, project A3 (renewed in 2014)
2007-2008: Member Selection Committee, DAAD, London office

Honors

Honors and Awards:

2017   Heisenberg-Professorship awarded by DFG
2012   Paul Schölmerich Award 2012
2010-  Emmy Noether Fellowship (DFG)
2004-2008 Feodor-Lynen Fellowship, Alexander von Humboldt Foundation

Publications

Selected Publications:

Kaminski, M.M., Tosic J., Kresbach, C., Engel, H., Klockenbusch, J., Müller, A.-L., Pichler, R., Grahammer, F., Kretz, O., Huber, T.B., Walz, G., Arnold, S.J.*, Lienkamp, S.S.* (2016). Direct Reprogramming of Fibroblasts into Renal Tubular Epithelial Cells by Defined Transcription Factors. Nat Cell Biol, Dec;18(12):1269-1280.  * corresponding authors  Abstract

Funk, M.C., Bera, A.N., Menchen, T., Kuales, G., Thriene, K., Lienkamp, S.S., Dengjel, J., Omran, H., Frank, M., and Arnold, S.J. (2015). Cyclin O (Ccno) functions in deuterosome-mediated centriole amplification of multiciliated cells. EMBO J 15;34(8):1078-89. Abstract

Zhu, D., Hölz, S., Metzger, E., Pavlovic, M., Galgoczy, P., Baer, C., Moser, M., Metzger, D., Günther, T.*, Arnold, S.J.*, and Schüle, R.* (2014). Lsd1 controls differentiation onset and migration in trophoblast stem cells. Nat Commun. 22; 5: 3174 * corresponding authors  Abstract

Klose, C.S.N., Flach, M., Möhle, L., Rogell, L., Hoyler, T., Ebert, Fabiunke, C., K., Pfeifer, D., Sexl, V., Souabni, A., Fonseca-Pereira, D., Domingues, R.G., Veiga-Fernandes, H., Arnold, S.J., Busslinger, M., Dunay, I.R., Tanriver, Y., and Diefenbach, A. (2014). Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages. Cell 157, 340-356. Abstract

Costello, I., Pimeisl, I.M., Dräger, S., Bikoff, E.K., Robertson, E.J., and Arnold, S.J. (2011). The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation. Nat Cell Biol 13(9), 1084-91. Abstract

Teo, A.K., Arnold, S.J., Trotter, M.W.B., Brown, S., Ang, L.T., Chng, Z., Robertson, E.J., Dunn, N.R., and Vallier, L. (2011). Pluripotency Factors Regulate Definitive Endoderm Specification through Eomesodermin. Genes Dev 25, 238-250. Abstract

Arnold, S.J. and Robertson, E.J. (2009). Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo. Nat Rev Mol Cell Biol 10, 91-103. Abstract

Arnold, S.J., Huang, G.J., Cheung, A.F.P., Era, T., Nishikawa, S., Bikoff, E.K., Molnar, Z., Robertson, E.J., and Groszer, M. (2008). The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone. Genes Dev 22, 2479-84. Abstract

Arnold, S.J., Hofmann, U.K., Bikoff, E.K., and Robertson, E.J. (2008). Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse. Development 135, 501-11. Abstract

Arnold, S.J., Maretto, S., Islam, A., Bikoff, E.K., and Robertson, E.J. (2006). Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo. Dev Biol 296, 104-18. Abstract

SGBM PhD students

SGBM PhD students:

CIBSS Track:

Chiara Schröder (since January 2019)


Alumni


Maja Funk (01/2013 - 12/2015)

Jelena Tosic (02/2015 - 01/2020)

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