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Contact
| Lab: | Prof. Dr. Sebastian Arnold |
| Department: | Institute for Clinical and Experimental Pharmacology and Toxicology Department II |
| Address: | Albertstr. 25 79104 Freiburg |
| Phone: | +49 761 203 96819 |
| E-mail: | This e-mail address is being protected from spambots. You need JavaScript enabled to view it |
| Lab homepage: | www.arnold-lab.com |
| BIOSS Excellence Cluster: | Associated member |
| PhD positions available: | YES |
| Research Area: | Developmental Biology |
| Research Interests: | - Signals & transcription factors guiding cell specification during early mouse development - Generation of differentiated cell types from pluripotent stem cells - Morphogenesis and cellular mechanisms of germ layer formation |
CV
| Education & Training: | 1994-2001 Medical training at the University of Freiburg |
| Employment & Experience: | since 2016: Group leader, Institute of Pharmacology, University of Freiburg 2017: Heisenberg-Professorship awarded by DFG 2010-2016: Emmy Noether Group Leader, University Medical Centre, Renal Department, Freiburg 2009-2010: Resident and Junior Group Leader, University Medical Centre, Renal Department, Freiburg 2004-2008: Postdoctoral Fellow, laboratory of Prof. E. J. Robertson, Cell and Developmental Biology, University of Oxford, UK 2002-2004: Clinical Resident, University Medical Centre, Renal Department, Freiburg |
| Scientific Activities: | since 2015: Member Executive Board Spemann Graduate School of Biology and Medicine (SGBM), Freiburg since 2015: Principal Investigator SFB 1140, Freiburg, project B07 since 2014: Member Executive Board SFB 850, Freiburg since 2011: Member Executive Board Center for Experimental Models and Transgenic Services (CEMT), Freiburg since 2011: Member Spemann Graduate School of Biology and Medicine (SGBM), Freiburg since 2011: Associated Member BIOSS, Centre for Biological Signalling Studies, Freiburg since 2010: Principal Investigator SFB 850, Freiburg, project A3 (renewed in 2014) 2007-2008: Member Selection Committee, DAAD, London office |
Honors
| Honors and Awards: | 2017 Heisenberg-Professorship awarded by DFG |
Publications
| Selected Publications: | Kaminski, M.M., Tosic J., Kresbach, C., Engel, H., Klockenbusch, J., Müller, A.-L., Pichler, R., Grahammer, F., Kretz, O., Huber, T.B., Walz, G., Arnold, S.J.*, Lienkamp, S.S.* (2016). Direct Reprogramming of Fibroblasts into Renal Tubular Epithelial Cells by Defined Transcription Factors. Nat Cell Biol, Dec;18(12):1269-1280. * corresponding authors Abstract Funk, M.C., Bera, A.N., Menchen, T., Kuales, G., Thriene, K., Lienkamp, S.S., Dengjel, J., Omran, H., Frank, M., and Arnold, S.J. (2015). Cyclin O (Ccno) functions in deuterosome-mediated centriole amplification of multiciliated cells. EMBO J 15;34(8):1078-89. Abstract Zhu, D., Hölz, S., Metzger, E., Pavlovic, M., Galgoczy, P., Baer, C., Moser, M., Metzger, D., Günther, T.*, Arnold, S.J.*, and Schüle, R.* (2014). Lsd1 controls differentiation onset and migration in trophoblast stem cells. Nat Commun. 22; 5: 3174 * corresponding authors Abstract Klose, C.S.N., Flach, M., Möhle, L., Rogell, L., Hoyler, T., Ebert, Fabiunke, C., K., Pfeifer, D., Sexl, V., Souabni, A., Fonseca-Pereira, D., Domingues, R.G., Veiga-Fernandes, H., Arnold, S.J., Busslinger, M., Dunay, I.R., Tanriver, Y., and Diefenbach, A. (2014). Differentiation of type 1 ILCs from a common progenitor to all helper-like innate lymphoid cell lineages. Cell 157, 340-356. Abstract Costello, I., Pimeisl, I.M., Dräger, S., Bikoff, E.K., Robertson, E.J., and Arnold, S.J. (2011). The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation. Nat Cell Biol 13(9), 1084-91. Abstract Teo, A.K., Arnold, S.J., Trotter, M.W.B., Brown, S., Ang, L.T., Chng, Z., Robertson, E.J., Dunn, N.R., and Vallier, L. (2011). Pluripotency Factors Regulate Definitive Endoderm Specification through Eomesodermin. Genes Dev 25, 238-250. Abstract Arnold, S.J. and Robertson, E.J. (2009). Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo. Nat Rev Mol Cell Biol 10, 91-103. Abstract Arnold, S.J., Huang, G.J., Cheung, A.F.P., Era, T., Nishikawa, S., Bikoff, E.K., Molnar, Z., Robertson, E.J., and Groszer, M. (2008). The T-box transcription factor Eomes/Tbr2 regulates neurogenesis in the cortical subventricular zone. Genes Dev 22, 2479-84. Abstract Arnold, S.J., Hofmann, U.K., Bikoff, E.K., and Robertson, E.J. (2008). Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse. Development 135, 501-11. Abstract Arnold, S.J., Maretto, S., Islam, A., Bikoff, E.K., and Robertson, E.J. (2006). Dose-dependent Smad1, Smad5 and Smad8 signaling in the early mouse embryo. Dev Biol 296, 104-18. Abstract |
SGBM PhD students
| SGBM PhD students: | CIBSS Track: Chiara Schröder (since January 2019)
Jelena Tosic (02/2015 - 01/2020) |
