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Contact
Lab: | Prof. Dr. Tanja Vogel |
Department: | Institute for Anatomy and Cell Biology Dept. Molecular Embryology |
Address: | Albertstr. 17 79104 Freiburg |
Phone: | +49 (0)761 203 5086 |
E-mail: | This e-mail address is being protected from spambots. You need JavaScript enabled to view it |
Lab homepage: | www.anatomie2.uni-freiburg.de/en/staff/vogel-1/index.htm |
PhD positions available: | YES |
Research Area: | Developmental Biology |
Research Interests: | 1. Epigenetic histone modifications in CNS development and function 2. Tgfβ signals in neuronal stem cell differentiation 3. Neurovascular coupling |
CV
Education & Training: | 10/1988-01/1994 Study of Biochemistry, University of Hannover, Degree: Diploma in Biochemistry, Tutor: Prof. J. Schmitdke 07/1994-11/1997 PhD work in Human Genetics, Institute for Human Genetics, Medical School Hannover, oral examination: 11/1997, Tutor: Prof. J. Schmidtke 2010 Habilitation in Anatomy, University Medical Center Göttingen, Department of Neuroanatomy |
Employment & Experience: | 10/1997-01/2000 Postdoctoral fellow, MRC Human Genetics Unit, Edinburgh, UK, Tutor: Prof. H.J. Cooke 02/2000-07/2005 Postdoctoral fellow, MPI for Biophysical Chemistry, Göttingen, Tutor: Prof. P. Gruss 08/2005-03/2011 Group leader, Department of Neuroanatomy, Centre for Anatomy, University Medical Center Göttingen 04/2011-01/2016 Associate Professor (W2), Department for Molecular Embryology, Institute for Anatomy and Cell Biology, University of Freiburg 01/2016-present Associate Professor (W3), Department for Molecular Embryology, Institute for Anatomy and Cell Biology, University of Freiburg 04/2014-present Managing Director of the Institute for Anatomy and Cell Biology, University of Freiburg |
Scientific Activities: | Referee duties for National Science Foundation (USA), Medical Research Council (UK), BBSRC (UK), INSERM (France), Deutsche Krebshilfe, Deutsche Forschungsgemeinschaft, German-Israeli Foundation (GIF), National Science Center (Poland). Scientific Journals: Cell and Tissue Research, Gene Expression Patterns, FEBS Letters, Journal of Vascular Research Editorial Board member of The International Journal of Developmental Neuroscience |
Honors
Honors and Awards: | 1994 - 1997: Doctoral fellowship from the Graduate School of the DFG “Molecular Pathophysiology of Cell Growth” |
Publications
Selected Publications: | Roidl D, Hellbach N, Bovio P, Villarreal A, Heidrich S, Nestel S, Grüning B, Bönisch U, Vogel T (2015) DOT1L activity promotes proliferation and protects cortical neural stem cells from activation of ATF4-DDIT3-mediated ER stress in vitro. Stem Cells, doi: 10.1002/stem.2187. Abstract Kosinsky RL, Wegwitz F, Hellbach N, Dobbelstein M, Mansouri A, Vogel T, Begus-Nahrmann Y, Johnsen SA (2015) Usp22 deficiency impairs intestinal epithelial lineage specification in vivo. Oncotarget 6(35):37906-18. Abstract Hellbach N, Weise SC, Vezzali R, Wahane SD, Heidrich S, Roidl D, Pruszak J, Esser JS, Vogel T. Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome. Hum Mol Genet. 2014 Dec 1;23(23):6177-90. doi: 10.1093/hmg/ddu338. Epub 2014 Jul 2. Abstract Wahane SD, Hellbach N, Prentzell MT, Weise SC, Vezzali R, Kreutz C, Timmer J, Krieglstein K, Thedieck K, Vogel T. PI3K-p110-alpha-subtype-signalling mediates survival, proliferation and neurogenesis of cortical progenitor cells via activation of mTORC2. J Neurochem. 2014 Mar 19. doi: 10.1111/jnc.12718. Abstract
Karpiuk O, Najafova Z, Kramer F, Hennion M, Galonska C, König A, Snaidero N, Vogel T, Shchebet A, Begus-Nahrmann Y, Kassem M, Simons M, Shcherbata H, Beissbarth T, Johnsen SA. The histone H2B monoubiquitination regulatory pathway is required for differentiation of multipotent stem cells. Mol Cell. 2012 Jun 8;46(5):705-13. doi: 10.1016/j.molcel.2012.05.022. Abstract Büttner N, Johnsen SA, Kügler S, Vogel T (2010) Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of upper layers in the cerebral cortex. Proc Natl Acad Sci U S A 107(15): 7042-7. Abstract |
SGBM PhD students
SGBM PhD students: |
Angelica Gray de Cristoforis (January 2016-June 2021) Ganeshkumar Arumugam (September 2014-May 2020) |