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Tanja Vogel Profile Page
Tanja Vogel


Lab: Prof. Dr. Tanja Vogel
Department: Institute for Anatomy and Cell Biology
Dept. Molecular Embryology
Address: Albertstr. 17
79104 Freiburg
Phone: +49 (0)761 203 5086
E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Lab homepage:
PhD positions available: YES
Research Area: Developmental Biology
Research Interests: 1. Epigenetic histone modifications in CNS development and function
2. Tgfβ signals in neuronal stem cell differentiation
3. Neurovascular coupling


Education & Training: 10/1988-01/1994 Study of Biochemistry, University of Hannover, Degree: Diploma in Biochemistry, Tutor: Prof. J. Schmitdke
07/1994-11/1997 PhD work in Human Genetics, Institute for Human Genetics, Medical
School Hannover, oral examination: 11/1997, Tutor: Prof. J. Schmidtke
2010 Habilitation in Anatomy, University Medical Center Göttingen, Department
of Neuroanatomy
Employment & Experience: 10/1997-01/2000 Postdoctoral fellow, MRC Human Genetics Unit, Edinburgh, UK, Tutor:
Prof. H.J. Cooke
02/2000-07/2005 Postdoctoral fellow, MPI for Biophysical Chemistry, Göttingen, Tutor: Prof.
P. Gruss
08/2005-03/2011 Group leader, Department of Neuroanatomy, Centre for Anatomy,
University Medical Center Göttingen
04/2011-01/2016 Associate Professor (W2), Department for Molecular Embryology, Institute for Anatomy and Cell Biology, University of Freiburg
01/2016-present Associate Professor (W3), Department for Molecular Embryology, Institute for Anatomy and Cell Biology, University of Freiburg
04/2014-present Managing Director of the Institute for Anatomy and Cell Biology, University of Freiburg
Scientific Activities: Referee duties for National Science Foundation (USA), Medical Research Council (UK), BBSRC (UK), INSERM (France), Deutsche Krebshilfe, Deutsche Forschungsgemeinschaft, German-Israeli Foundation (GIF), National Science Center (Poland).

Scientific Journals: Cell and Tissue Research, Gene Expression Patterns, FEBS Letters, Journal of Vascular Research

Editorial Board member of The International Journal of Developmental Neuroscience


Honors and Awards:

1994 - 1997: Doctoral fellowship from the Graduate School of the DFG “Molecular Pathophysiology of Cell Growth”
1998 - 2000: Travelling Research Fellowship of the Wellcome Trust, UK
2000 - 2001: Postdoctoral Fellowship of the Max-Planck-Society
2011: Award for the best Habilitation of the University Medicine Göttingen
2015: Invitation for associate professor (W3), Department of Molecular Embryology, University of Freiburg


Selected Publications:

Roidl D, Hellbach N, Bovio P, Villarreal A, Heidrich S, Nestel S, Grüning B, Bönisch U, Vogel T (2015) DOT1L activity promotes proliferation and protects cortical neural stem cells from activation of ATF4-DDIT3-mediated ER stress in vitro. Stem Cells, doi: 10.1002/stem.2187. Abstract

Kosinsky RL, Wegwitz F, Hellbach N, Dobbelstein M, Mansouri A, Vogel T, Begus-Nahrmann Y, Johnsen SA (2015) Usp22 deficiency impairs intestinal epithelial lineage specification in vivo. Oncotarget 6(35):37906-18. Abstract

Hellbach N, Weise SC, Vezzali R, Wahane SD, Heidrich S, Roidl D, Pruszak J, Esser JS, Vogel T. Neural deletion of Tgfbr2 impairs angiogenesis through an altered secretome. Hum Mol Genet. 2014 Dec 1;23(23):6177-90. doi: 10.1093/hmg/ddu338. Epub 2014 Jul 2. Abstract

Wahane SD, Hellbach N, Prentzell MT, Weise SC, Vezzali R, Kreutz C, Timmer J, Krieglstein K, Thedieck K, Vogel T. PI3K-p110-alpha-subtype-signalling mediates survival, proliferation and neurogenesis of cortical progenitor cells via activation of mTORC2. J Neurochem. 2014 Mar 19. doi: 10.1111/jnc.12718. Abstract

Karpiuk O, Najafova Z, Kramer F, Hennion M, Galonska C, König A, Snaidero N, Vogel T, Shchebet A, Begus-Nahrmann Y, Kassem M, Simons M, Shcherbata H, Beissbarth T, Johnsen SA. The histone H2B monoubiquitination regulatory pathway is required for differentiation of multipotent stem cells. Mol Cell. 2012 Jun 8;46(5):705-13. doi: 10.1016/j.molcel.2012.05.022. Abstract

Büttner N, Johnsen SA, Kügler S, Vogel T (2010) Af9/Mllt3 interferes with Tbr1 expression through epigenetic modification of histone H3K79 during development of upper layers in the cerebral cortex. Proc Natl Acad Sci U S A 107(15): 7042-7. Abstract

Vogel T, Ahrens S, Buttner N, Krieglstein K (2009) Transforming Growth Factor β Promotes Neuronal Cell Fate of Mouse Cortical and Hippocampal Progenitors In Vitro and In Vivo: Identification of Nedd9 as an Essential Signaling Component. Cereb Cortex 20(3):661-71. Abstract

Schulz R, Vogel T, Mashima T, Tsuruo T, Krieglstein K (2009) Involvement of fractin in TGF-beta-induced apoptosis in oligodendroglial progenitor cells. Glia 57(15):1619-29. Abstract

Britanova O, de Juan RC, Cheung A, Kwan KY, Schwark M, Gyorgy A, Vogel T, Akopov S, Mitkovski M, Agoston D, Sestan N, Molnar Z, Tarabykin V (2008) Satb2 is a postmitotic determinant for upper-layer neuron specification in the neocortex. Neuron 57: 378-392. Abstract

Vogel T, Stoykova A, Gruss P (2006) Differential expression of polycomb repression complex 1 (PRC1) members in the developing mouse brain reveals multiple complexes. Dev Dyn 235: 2574-2585. Abstract

SGBM PhD students

SGBM PhD students:

Angelica Gray de Cristoforis (since January 2016)


Ganeshkumar Arumugam (September 2014-May 2020)

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