Principal Investigators

Displaying 1 - 93 of 93
Name Research Area & Research interests Memberships
Asifa Akhtar's picture Asifa Akhtar
Max Planck Institute of Immunobiology and Epigenetics
Protein Structure and Function

- Chromatin and epigenetic regulation

CIBSS, SFB1381, SFB1425

Sonja Albers's picture Sonja Albers
Institute of Biology II
Protein Structure and Function

- Biogenesis of the archaeal cell envelope / Assembly of macromolecular structures in the archaeal cell envelope / Regulation of archaellum biosynthesis / Signaltransduction cascades and the involvement of protein phosphorylation / Development of genetic tools for different archaeal species

CIBSS, SFB1381

Susana Andrade's picture Susana Andrade
Institute of Biochemistry
Protein Structure and Function

- Structure, function and regulation of membrane proteins involved in ion transport and sensing mechanisms

Sebastian Arnold's picture Sebastian Arnold
Institute of Experimental and Clinical Pharmacology and Toxicology - Department II
Developmental Biology

- Signals & transcription factors guiding cell specification during early mouse development / Generation of differentiated cell types from pluripotent stem cells / Morphogenesis and cellular mechanisms of germ layer formation

CIBSS, SFB1453

Marlene Bartos's picture Marlene Bartos
Institute of Physiology I
Neurosciences

- Cellular basis of information processing in the brain. Our goal is to understand how information is encoded, stored and retrieved from neuronal networks.

BL-BT

Ralf Baumeister's picture Ralf Baumeister
Institute of Biology III
Molecular Medicine

- Molecular genetics and biochemistry of aging and age-related diseases

CIBSS, SFB1381

Bertram Bengsch's picture Bertram Bengsch
Clinic for Internal Medicine II
Molecular Medicine

- Mechanisms of T cell exhaustion and tissue residency / Regulation of immune responses in Cancer, viral infection and autoimmunity / Immunometabolism / Systems immunology / Mass cytometry and imaging mass cytometry

CIBSS, EURIdoc

Matthias Boll's picture Matthias Boll
Institute of Biology II
Protein Structure and Function

- Enzymes and metabolites involved in the degradation of aromatic pollutants in anaerobic bacteria.

SFB1381

Johann Bollmann's picture Johann Bollmann
Institute of Biology I
Neurosciences

- Understanding neural circuits and underlying behavior in genetic model organisms, using genetics, functional imaging and electrophysiology / Visual information processing and motor control in the vertebrate central nervous system / Development of neural circuits in the zebrafish model system.

Christoph Borner's picture Christoph Borner
Institute for Molecular Medicine and Cell Research
Molecular Medicine

- Elucidation of the function of anti- and pro-apoptotic Bcl-2 family members / Characterization of components of RNA-virus (SFV)- and DNA-virus (HSV-1)-induced apoptosis signaling / Elucidation of the apoptotic and pro-inflammatory signaling pathways of the Aspergillus fumigatus toxin gliotoxin to prevent human Aspergillosis.

Priscilla Briquez's picture Priscilla Briquez
Dept. of General and Visceral Surgery, University Medical Center
Molecular Medicine

- We use protein engineering approaches to design novel drug delivery systems that target and modulate the immune response in inflamed tissues. Our research aims to develop or improve immunotherapies in cancer and regenerative medicine.

Tilman Brummer's picture Tilman Brummer
Institute of Molecular Medicine and Cell Research
Molecular Medicine

- Our main scientific interest is to understand the mechanisms by which cells convert the information of extracellular signals, e.g. hormones, growth factors or antigens, into intracellular signals and how these events steer physiological and pathological processes such as cancer.

Maria Stella Carro's picture Maria Stella Carro
Department of Neurosurgery, University Medical Center
Molecular Medicine

- My research focuses on the role and regulation of ZBTB18, a transcriptional repressor and tumor suppressor in the brain, which halts mesenchymal transformation of glioblastoma cells by counteracting key tumorigenic mechanisms such as fatty acid synthesis and the recruitment of pro-tumorigenic microglia.

Toni Cathomen's picture Toni Cathomen
Institute for Transfusion Medicine and Gene Therapy
Molecular Medicine

- Improvement of TALEN and CRISPR-Cas platforms for therapeutic applications in human stem cells / Development of disease models and cell therapies based on induced pluripotent stem cells (iPSCs) / Translation of cell and gene therapies for patients suffering from primary immunodeficiencies, HIV infection, and leukemia into the clinic.

Anne-Kathrin Classen's picture Anne-Kathrin Classen
Institute of Biology II / Hilde Mangold Haus
Developmental Biology

- Signalling and proliferation during tissue regeneration / Epithelial architecture and biomechanics / Chromatin and epigenetic plasticity

CIBSS

Sven Diederichs's picture Sven Diederichs
Division of Cancer Research, Department of Thoracic Surgery, University Medical Center
Molecular Medicine

- Understanding molecular mechanisms of lung cancer and metastasis / Focus on RNA Biology and long non-coding RNAs / Approaches of Molecular Biology, Cell Biology & Bioinformatics

SFB1453

Máté Döbrössy's picture Máté Döbrössy
Dept. of Stereotactic and Functional Neurosurgery, University Medical Center
Neurosciences

- The behavioral, physiological and biological consequences of neurostimulation (e.g. DBS, optogenetics, focused ultrasound) in experimental models of Depression; and the neurobiology and the neurocircuitry associated with Depression.

Wolfgang Driever's picture Wolfgang Driever
Institute of Biology I
Developmental Biology

- Embryonic Development of Vertebrates (Zebrafish) / Development of dopaminergic neurons / Dopaminergic modulation of neural circuit function and behavior

CIBSS

Stefan Ehl's picture Stefan Ehl
Centre for Chronic Immunodeficiency, University Medical Center
Immunology and Virology

- The group „Human T-cell immunodeficiency“ works at the interface of clinical and basic research focussing on human T cell immunity. The projects range from the identification of novel gene defects followed by pathophysiological studies to the development of novel diagnostic tools and therapies.

Oliver Einsle's picture Oliver Einsle
Institute of Biochemistry
Protein Structure and Function

- Structure and Function of Membrane Proteins and Metalloproteins

SFB1381

Miriam Erlacher's picture Miriam Erlacher
Center for Pediatrics and Adolescent Medicine, University Medical Center
Molecular Medicine

- Apoptosis signaling / Haematopoietic stem cell biology / Bone marrow failure / Myelodysplastic syndromes / Leukemia / Stem cell transplantation

Kilian Eyerich's picture Kilian Eyerich
Dept. of Dermatology and Venereology, University Medical Center
Molecular Medicine

- Inflammatory skin diseases, dermato-immunology, interaction of lymphocytes and resident skin cells, molecular classification.

Ian Frew's picture Ian Frew
Division of Hematology, Oncology and Stem Cell Transplantation, University Medical Center
Molecular Medicine

- Understanding how combinations of genetic mutations affect tumour phenotypes and responses to therapies / Development and use of novel genetic tools allowing high throughput genetics to model complex human tumours in mice / Genetic and chemical library screening to identify novel mutation-specific therapeuties

SFB1453

Thorsten Friedrich's picture Thorsten Friedrich
Institute of Biochemistry
Protein Structure and Function

- Mitochondria and bacteria respiratory complex I, the first complex of cell respiration

Florian Full's picture Florian Full
Institute of Virology
Immunology and Virology

- Elucidating the role of the germline transcription factor DUX4 in herpesviral infections / Evaluate the transcription factor DUX4 as novel target for anti-herpesviral therapy / Characterize the epigenetics of the herpesviral genome / Identification and characterization of antiviral restriction factors for poxviruses

Bodo Grimbacher's picture Bodo Grimbacher
Center of Chronic Immunodeficiency, University Medical Center
Immunology and Virology

- Genetic causes of hypogammaglobulinemia (CVID) / The clinical phenotype of antibody deficiency syndromes / The genetic cause of the hyper-IgE recurrent infection syndrome (HIES) / New disease genes in severe congenital neutropenia (SCN) / The genetic cause of chronic mucocutaneous candidiasis (CMC) / The molecular pathology of chronic inflammatory bowel disease

CIBSS, EURIdoc

Robert Grosse's picture Robert Grosse
Institute for Clinical and Experimental Pharmacology and Toxicology, Department I
Synthetic Biology and Signalling

- Signal regulation of the actin cytoskeleton / Nuclear actin assembly and chromatin dynamics in signaling and mitosis / Invasive cancer cell migration / Optogenetic control of actin regulators / High resolution live cell imaging

CIBSS, SFB1453

Georg Haecker's picture Georg Haecker
Institute of Microbiology and Hygiene
Immunology and Virology

- Molecular and Cellular Immunology

EURIdoc

Sjon Hartman's picture Sjon Hartman
Institute of Biology III / Hilde Mangold Haus
Molecular Plant Sciences

- Plant (root) responses to the environment, with a focus on plant submergence / Ethylene and low-oxygen signaling / Epigenetic stress memory

CIBSS

Tanja Hartmann's picture Tanja Hartmann
Clinic for Internal Medicine I, University Medical Center
Molecular Medicine

- Malignant and normal cell homing, microenvironment, cytoskeleton, integrins, leukemia.

Andreas Hecht's picture Andreas Hecht
Institute of Molecular Medicine and Cell Research
Molecular Medicine

- Invasion and metastasis in colorectal cancer using human cell lines and mouse intestinal organoids as model systems / Regulatory networks initiating and executing epithelial-mesenchymal transitions / Functional interplay of transcription factors and chromatin structure at cis-regulatory DNA elements

Lutz Hein's picture Lutz Hein
Institute of Experimental and Clinical Pharmacology and Toxicology, Department II
Molecular Medicine

- GPCR signaling in the cardiovascular system / Cell-type specific signaling mechanisms in the heart / Epigenetic mechanisms of physiological and pathological gene expression / Cardiovascular pharmacology

SFB1425

Hartmut Hengel's picture Hartmut Hengel
Institute of Virology
Immunology and Virology

- Our research interest is covering virology and immunology. We focus on both cytomegalovirus-encoded and host-encoded Fc-Receptors. The former are potent manipulators of IgG and innate humoral immunity, the latter implicated in antiviral defence but also immunopathology.

EURIdoc

Philipp Henneke's picture Philipp Henneke
Center for Chronic Immunodeficiency, Center of Pediatrics and Adolescent Medicine
Immunology and Virology

- Development of cellular innate immunity against commensals of the skin (staphylococci) and respiratory/intestinal tract (streptococci) at the beginning of life in humans and mice / Receptor-based recognition of bacterial effectors, in particular lipopetides and cytolysins, by macrophages and neutrophils

CIBSS, EURIdoc

Tobias Hermle's picture Tobias Hermle
Department of Medicine, Renal Division, University Medical Center
Molecular Medicine

- Molecular mechanisms of genetic kidney diseases / Biology of the renal filtration barrier / Endocytosis and trafficking of the slit diaphragm protein nephrin / We combine human genetic analyses with animal models (Drosophila and mouse) and whole organism drug screening

SFB1453

Simone Hettmer's picture Simone Hettmer
University Medical Center
Molecular Medicine

- Research in our lab aims at a better understanding of cellular and molecular drivers of sarcoma initiation and maintenance through: i. characterization of the sarcoma-initiating capacities of mesodermal precursor cell populations; ii. investigation of the genetic basis of sarcoma susceptibility / Development of sarcoma test platforms in vitro and in mice

Ingo Hilgendorf's picture Ingo Hilgendorf
Department of Cardiology and Angiology I, UHZ
Molecular Medicine

- Identification of inflammatory processes responsible for the imbalanced immune response in atherosclerosis, myocardial infarction and other cardiovascular diseases / Defining feasible targets for immunomodulation to restore proper resolution of inflammation

SFB1425

Valérie Hilgers's picture Valérie Hilgers
Max Planck Institute of Immunobiology and Epigenetics Freiburg
Developmental Biology

- Alternative RNA processing in nervous system development and function / Regulation of the neuronal non-coding transcriptome / Molecular mechanisms of neurological disease.

CIBSS

Andreas Hiltbrunner's picture Andreas Hiltbrunner
Institute of Biology II, Dept. of Molecular Plant Physiology
Molecular Plant Sciences

- Molecular mechanisms of light perception an downstream signalling in seed plants and cryptogams (e.g. Arabidopsis thaliana, Physcomitrella patens) / Evolution of light signalling in plants / Phytochrome signalling / Integration of light, hormone, and environmental signalling

CIBSS

Ulrich Hofmann's picture Ulrich Hofmann
Section of Neuroelectronic Systems, Department of Neurosurgery
Neurosciences

- Pre-clinical Bioelectronic Medicine, Neuro-Technology, longevity of Brain-Machine Interfaces, infrared, electrical and magnetic stimulation of the nervous system, nanoparticles for imaging and intervention, magnetic fluid hyperthermia in vivo and in vitro, Theranostics. Next-gen sequencing, fluorescence microscopy and signal processing, electric field sensors for environmental monitoring. Tool building.

Carola Hunte's picture Carola Hunte
Institute for Biochemistry and Molecular Biology
Protein Structure and Function

- Structure and mechanism of medically relevant membrane proteins, bioenergetics, ion transport, biological signalling, structural lipids.

CIBSS, SFB1381, SFB1453

Bernd Kammerer's picture Bernd Kammerer
Hilde Mangold Haus
Molecular Medicine

- Regulation of plant biochemical pathways to investigate central metabolism, biosynthesis of secondary metabolites, signalling and stress response / Metabolomics to unravel molecular mechanisms involved in Parkinson's disease and neurodegeneration / Biomarker identification in cancer / Analysis of the mitochondrial metabolome/ Metabolomics of prostate cancer.

Katrin Kierdorf's picture Katrin Kierdorf
Institute of Neuropathology, University Medical Center
Immunology and Virology

- Our research group takes advantage of transgenic mice, Drosophila and cell culture systems to understand the molecular machineries guiding the development and diversity of tissue-resident macrophages and how these cells communicate throughout their network and with host tissue cells during homeostasis and disturbance.

CIBSS

Jürgen Kleine-Vehn's picture Jürgen Kleine-Vehn
Institute of Biology II, Dept. of Molecular Plant Physiology
Molecular Plant Sciences

- We use cell biological and biochemical approaches to study plant (cell) size determination at a molecular, subcellular, and organ scale. Our research unravels hormonal control of plant growth and thereby mechanistically characterizes traits of agricultural significance.

CIBSS

Hans-Georg Koch's picture Hans-Georg Koch
Institute of Biochemistry and Molecular Biology
Protein Structure and Function

- Our work is focused on bacterial cell biology. By biochemical methods and molecular imaging approaches we explore targeting pathways of proteins and mRNAs, we determine how cells respond to stress conditions and how protein machineries are assembled.

SFB1381

Georg Kochs's picture Georg Kochs
Institute of Virology
Immunology and Virology

- Molecular biology of Orthomyxoviruses, Influenza A- and tick-transmitted Thogoto virus / Role of viral IFN antagonists for virulence in the mouse model / Antiviral function of Mx proteins / Evolution of Mx proteins in primates, rodents and bats.

Peter Kohl's picture Peter Kohl
Institute for Experimental Cardiovascular Medicine
Molecular Medicine

- Investigation of cardiac structure-function relations, using wet- and dry-lab techniques, with the aim of 'making better scars' in the heart.

CIBSS, SFB1425

Maja Köhn's picture Maja Köhn
Institute of Biology III
Protein Structure and Function

- Elucidation of the functions and molecular mechanisms of the cancer-promoting phosphatase PRL-3 and the ubiquitous phosphatase PP1 / Development of inhibitors and activators for phosphatases

CIBSS, SFB1381

Michael Köttgen's picture Michael Köttgen
Dept. of Internal Medicine IV, University Medical Center
Molecular Medicine

- Physiological and pathological functions of proteins involved in monogenic and complex genetic diseases, polycystic kidney disease, gout, TRP channels, calcium signaling, biology of cilia.

CIBSS, SFB1453

Anna Köttgen's picture Anna Köttgen
Institute of Genetic Epidemiology, University Medical Center
Molecular Medicine

- Genetic Epidemiology / Complex kidney and metabolic diseases / Transport mechanisms in the kidney / Monogenic kidney and solute transport diseases / Population-based studies / Pharmacogenomics / Use of genetic information for personalized health care, prevention.

CIBSS, SFB1453

Claudine Kraft's picture Claudine Kraft
Institute of Biochemistry and Molecular Biology
Protein Structure and Function

- Our group aims at understanding how the molecular machinery of autophagy, the cellular waste disposal system, works.

CIBSS, SFB1381

Akos Kulik's picture Akos Kulik
Institute of Physiology II
Neurosciences

- Subcellular organization and functional interaction of metabotropic receptors and their effector ion channels / Dynamics of the surface expression and subunit composition of synapse-related proteins / Activity-dependent structural and molecular alterations of central neurons / High-resolution quantitative immunoelectron microscopy / Electrophysiology / Pharmacology

Johannes Letzkus's picture Johannes Letzkus
Institute of Physiology I
Neurosciences

- The overarching aim of my lab is to understand mechanistically how neocortex contributes to higher brain functions such as sensory perception, memory and attention. Specifically, we focus on: i) The organization and function of neocortical layer 1, a major site for processing of internally-generated top-down information; ii) The contributions of different types of inhibitory interneurons to higher brain functions; iii) The brain-wide afferent systems that send internally-generated top-down information into neocortex; iv) The brain areas and circuit mechanisms of learning and memory

Diana Lindner's picture Diana Lindner
Dept. of Cardiology and Angiology, UHZ
Molecular Medicine

- Pathophysiology of heart failure / mouse models with experimentally induced heart failure (e.g. myocardial infarction or viral myocarditis) / interplay of cardiac inflammation and fibrotic remodelling / in vitro cell culture experiments to elucidate the molecular mechanisms.

Ulrich Maurer's picture Ulrich Maurer
Institute of Molecular Medicine and Cell Research
Molecular Medicine

- Signaling of cell death and survival

Chris Meisinger's picture Chris Meisinger
Institute of Biochemistry and Molecular Biology
Protein Structure and Function

- Signaltransduction in mitochondrial protein import / Mitochondrial signal switches in tumor diseases / Mitochondrial protein quality control in Alzeimer’s disease

CIBSS, SFB1381

Susana Minguet's picture Susana Minguet
Institute of Biology III - Molecular immunology
Immunology and Virology

- The molecular mechanisms of early T cell activation and how this knowledge can be used for treatments of human diseases / The complex interplay between the biophysical properties of the extracellular matrix and T cell infiltration to improve tumor immunotherapy / The nano-organization of the B cell antigen receptor and the mechanisms by which defective B cell activation leads to immunopathology

CIBSS

Annette Neubüser's picture Annette Neubüser
Institute of Biology I
Developmental Biology

- Molecular mechanisms of craniofacial development / Development of the sensory placodes / Feather development

Gabriele Niedermann's picture Gabriele Niedermann
Department of Radiation Oncology, University Medical Center
Immunology and Virology

- Tumor Immunology / Tumor Immunotherapy / Radiobiology / Molecular Imaging

Heike Pahl's picture Heike Pahl
Section of Molecular Hematology, Clinic for Internal Medicine I, University Medical Center
Molecular Medicine

- Molecular markers in Myeloproliferative Disorders / The role of transcription factor NF-E2 -Molecular etiology of NF-E2 and PRV-1 Overexpression in MPD / Molecular heterogeneity in Essential Thrombycythemia / Mouse models of myeloproliferative disorders

Nikolaus Pfanner's picture Nikolaus Pfanner
Institute of Biochemistry and Molecular Biology
Protein Structure and Function

- Mechanisms of intracellular protein sorting with a focus on targeting and assembly of mitochondrial proteins.

CIBSS

Sebastian Preissl's picture Sebastian Preissl
Institute of Experimental and Clinical Pharmacology and Toxicology
Molecular Medicine

- Epigenetic regulation of cardiovascular cell types / Transcriptional control of cardiovascular diseases / Molecular characterization of genetic variants / Single cell genomics, epigenomics, functional genomics

CIBSS, SFB1453

Georgios Pyrowolakis's picture Georgios Pyrowolakis
Institute of Biology I / Hilde Mangold Haus
Developmental Biology

- Signal Transduction / Analysis of Drosophila BMP-signaling / Formation and interpretation of morphogen gradients / Germline stem cells / Organogenesis.

CIBSS

Michael Quante's picture Michael Quante
Clinic for Internal Medicine II, University Medical Center
Molecular Medicine

- Pathogenesis of Barrett's esophagus (BE) and the resulting adenocarcinoma of the esophagus (EAC)

Thomas Reinheckel's picture Thomas Reinheckel
Institute for Molecular Medicine and Cell Research
Molecular Medicine

- Involvement of proteolytic enzymes in cellular signalling processes concerning cancer and neurological diseases.

Ralf Reski's picture Ralf Reski
Institute of Biology II
Molecular Plant Sciences

- Gene expression (transcripts, proteins, protein modifications, metabolites, sub-cellular integration) in the moss Physcomitrella patens

CIBSS

Michael Reth's picture Michael Reth
Institute of Biology III
Synthetic Biology and Signalling

- Organisation and regulation of intracellular signalling pathways in normal and diseased lymphocytes / Rebuilding the signaling pathways from the B cell antigen receptor / Cre/loxP technique for the B cell specific induction or deletion of genes in the mouse

BIOSS, CIBSS

Eva Rog-Zielinska's picture Eva Rog-Zielinska
Institute for Experimental Cardiovascular Medicine
Molecular Medicine

- Structural and functional properties of atrial and ventricular T-tubules / Nano-to-micro scale investigation of the impact of mechanical activity on cardiac T-tubular system and other subcellular domains / Interactions between myocytes and non-myocytes in the heart (structural and functional) / Structural remodelling during heart disease and reverse remodelling

SFB1425

Winfried Römer's picture Winfried Römer
Institute of Biology II
Synthetic Biology and Signalling

- Our research focuses on host-pathogen interactions. We are interested in understanding the impact of diverse bacterial virulence factors on host cell physiology. For instance, we aim at elucidating how the Pseudomonas aeruginosa lectins LecA and LecB impair wound healing processes. To achieve our scientific goals, we usually combine “complex”, analytical approaches with “minimal”, synthetic approaches.

BIOSS, CIBSS

Christian Schachtrup's picture Christian Schachtrup
Institute for Anatomy and Cell Biology, Dept. Molecular Embryology
Neurosciences

- Understanding blood-derived coagulation factors in orchestrating CNS scar formation and harnessing Neural Stem Cells (NSCs) for improving CNS repair. We are testing the effects of modified endogenous NSCs and modified transplanted iPSC-derived NSCs on immunmodulation, scar formation and functional regeneration.

Wolfgang Schamel's picture Wolfgang Schamel
Institute of Biology III
Immunology and Virology

- Define the protein complexes that change in time and space within the signaling cascades of the antigen TCR

BIOSS, CIBSS, EURIdoc, SFB1381

Christoph Schell's picture Christoph Schell
Institute of Surgical Pathology
Molecular Medicine

- Cell-matrix interactions in specialized renal epithelial cells (incldg. podocytes, proximal renal epithelial cells) / Characterization of key events modulating chronic interstitial fibrosis / Characterization and functional elucidation of the tumor matrisome in clear cell renal cell carcinoma (ccRCC) / Functional analysis of molecular subtypes of urothelial cell carcinoma

SFB1453

Oliver Schilling's picture Oliver Schilling
Institute of Surgical Pathology
Molecular Medicine

- We apply innovative proteomic and degradomic techniques to understand how proteolysis contributes to physiological and pathological processes. With over 560 proteases in man, this enzyme family ranks among the most abundant protein classes, illustrating its ubiquitous importance in human biology. We understand proteolysis as a post-translational modification that regulates protein location, function, and abundance.

SFB1453

Miriam Schmidts's picture Miriam Schmidts
Center for Pediatrics and Adolescent Medicine, University Medical Center
Molecular Medicine

- Gene discovery: the genetic basis of rare diseases with main focus on motile and non-motile ciliopathies, neurodevelopmental disorders and inherited renal diseases / Elucidating the molecular mechanisms underlying rare diseases using gene editing approaches in vitro and in vivo

CIBSS, SFB1453

Franziska Schneider-Warme's picture Franziska Schneider-Warme
Institute for Experimental Cardiovascular Medicine
Molecular Medicine

- Design and implementation of new optogenetic tools for modulating the activity of excitable cells and tissues / Development of optogenetic approaches for functionally dissecting electrical interactions between cardiac cell populations / Electrophysiological characterization of cardiac non-myocytes / 3D reconstruction of cellular networks in healthy and diseased hearts.

CIBSS, SFB1425

Andreas Schulze-Bonhage's picture Andreas Schulze-Bonhage
Freiburg Epilepsy Center, Department of Neurosurgery
Neurosciences

- Clinical neurophysiology, EEG-correlates of cognition and EEG-biomarkers of disease, as well as electrical interference with physiological brain processing and with pathological activity (epilepsy)

Martin Schwemmle's picture Martin Schwemmle
Institute of Virology
Immunology and Virology

- Species transmission of highly pathogenic influenza A viruses / Emerging bat viruses / Innate immunity / Neurotropic viruses

Khaled Selim's picture Khaled Selim
Institute of Biology II
Protein Structure and Function

- Metabolic Engineering / Synthetic pathways / Molecular and structural mechanisms for coordination of carbon/nitrogen metabolism in prokaryotes / Cell signaling with special emphasis on PII signaling superfamily and second messengers signaling (c-di-AMP, c-di-GMP and Ca2+ signaling) / Membrane transporters / Cyanobacterial multicellularity and developmental processes.

SFB1381

Andrew Straw's picture Andrew Straw
Institute of Biology I, Dept. of Neurobiology and Behavior
Neurosciences

- Neural circuits of visual reflexes and visual navigation in Drosophila / Technology development for neurobiology and neuroethology / Neurogenetic, including optogenetic, approaches to neural circuit function

Robert Thimme's picture Robert Thimme
Clinic for Internal Medicine II, University Medical Center
Immunology and Virology

- My research focus lies on the immune responses in hepatitis B virus (HBV) and hepatitis C virus (HCV) infection as well as hepatocellular carcinoma (HCC), specifically the immunological determinants of viral clearance and persistence.

EURIdoc

Marc Timmers's picture Marc Timmers
Centre for Clinical Research (ZKF), University Medical Center
Molecular Medicine

- Epigenetic control in cancer, Chromatin complexes, Histone modifications, Gene transcription. / Methods: genome-wide profiling, quantitative mass spectrometry, interaction proteomics, epigenetic drug screens.

SFB1453

Maximilian Ulbrich's picture Maximilian Ulbrich
Department of Internal Medicine IV
Synthetic Biology and Signalling

- Membrane protein assembly / Single molecule imaging / Superresolution / Biophysics of receptors in neuroscience / Immunology and signalling

Julia Veit's picture Julia Veit
Institute of Physiology I
Neurosciences

- Systems neuroscience / Cortical circuits / Visual cortex / Interareal interactions / Optogenetics / Neuropixels / Electrophysiology / Oscillations / Interneurons

Andreas Vlachos's picture Andreas Vlachos
Institute for Anatomy and Cell Biology, Dept. of Neuroanatomy
Neurosciences

- Structural and functional plasticity of neurons and their molecular regulation / Role of homeostatic plasticity at the interface between health and disease / Cellular and molecular mechanisms of transcranial magnetic stimulation (TMS) / Impact of neuroinflammation and neurocoagulation on neuro-glial interactions and synaptic plasticity

Tanja Vogel's picture Tanja Vogel
Institute for Anatomy and Cell Biology, Dept. of Molecular Embryology
Developmental Biology

- How epigenetic modifications instruct stem cells during central nervous system development / FOXG1 and the aetiology of FOXG1-syndrome / Signaling to chromatin with a focus on TGF-signaling

Nora Vögtle's picture Nora Vögtle
Centre for Molecular Biology Heidelberg, University of Heidelberg
Protein Structure and Function

- Our group wants to understand the role of mitochondrial proteases in the maintenance of the mitochondrial proteome. We use yeast, mammalian and patient cells to investigate the pathophysiological consequences of dysfunctions in these proteases that result in severe neurodegenerative diseases and cardiomyopathies.

CIBSS, SFB1381

Peter Walentek's picture Peter Walentek
Dept. of Internal Medicine IV, University Medical Center
Developmental Biology

- We study signaling, epigenetic, transcriptional and post-transcriptional regulation of gene regulatory networks, and the processes that facilitate tissue formation and function. This provides insights into the logic of self-organization in biological systems and the mechanisms underlying ciliopathies and lung diseases.

CIBSS, SFB1453

Gerd Walz's picture Gerd Walz
Dept. of Internal Medicine IV, University Medical Center
Molecular Medicine

- Pathogenesis of renal cystic disease

CIBSS, SFB1453

Wilfried Weber's picture Wilfried Weber
Institute of Biology II
Synthetic Biology and Signalling

-

BIOSS, CIBSS

Nils Wiedemann's picture Nils Wiedemann
Institute of Biochemistry and Molecular Biology
Protein Structure and Function

- Biogenesis of mitochondrial beta-barrel membrane proteins and alpha-helical outer membrane proteins / Import, sorting, insertion and assembly of mitochondrial alpha-helical inner membrane proteins / Assembly of respiratory chain complexes / Analysis of the mitochondrial proteome in yeast and human cells.

CIBSS, SFB1381

Annegret Wilde's picture Annegret Wilde
Institute of Biology III
Molecular Plant Sciences

- Investigations on phototaxis using different photoreceptors / Elucidating the potential of cyanobacteria as producers of amino acids, proteins as well as biofuels / Investigations on the role of RNA-based regulators in bacteria / Characterisation of photosynthetic functions, light-harvesting and its regulation / Studies on the circadian clock of cyanobacteria

SFB1381

Dennis Wolf's picture Dennis Wolf
Dept of Cardiology and Angiology, UHZ, University Medical Center
Molecular Medicine

-

SFB1425

Robert Zeiser's picture Robert Zeiser
Department of Hematology and Oncology, University Medical Center
Immunology and Virology

- Tumor immunology, oncogenic signaling, allogeneic hematopoietic cell transplantation (allo-HCT), Graft-versus-host disease (GVHD), Anti-leukemia immune responses, immune checkpoint blockade therapy (ICB), immune related adverse events (irAEs).

CIBSS