Principal Investigators

- Genetic causes of hypogammaglobulinemia (CVID) / The clinical phenotype of antibody deficiency syndromes / The genetic cause of the hyper-IgE recurrent infection syndrome (HIES) / New disease genes in severe congenital neutropenia (SCN) / The genetic cause of chronic mucocutaneous candidiasis (CMC) / The molecular pathology of chronic inflammatory bowel disease

- Our research interest is covering virology and immunology. We focus on both cytomegalovirus-encoded and host-encoded Fc-Receptors. The former are potent manipulators of IgG and innate humoral immunity, the latter implicated in antiviral defence but also immunopathology.

- Our research group takes advantage of transgenic mice, Drosophila and cell culture systems to understand the molecular machineries guiding the development and diversity of tissue-resident macrophages and how these cells communicate throughout their network and with host tissue cells during homeostasis and disturbance.

- The molecular mechanisms of early T cell activation and how this knowledge can be used for treatments of human diseases / The complex interplay between the biophysical properties of the extracellular matrix and T cell infiltration to improve tumor immunotherapy / The nano-organization of the B cell antigen receptor and the mechanisms by which defective B cell activation leads to immunopathology

- Define the protein complexes that change in time and space within the signaling cascades of the antigen TCR

- Understanding the role of T-box transcription factors, T-bet and Eomesodermin, in innate and adaptive immunity, their redundancy, overlap and specific functions. Translating basic immunology to new models of immune-mediated kidney disease, e.g. allograft rejection after kidney transplantation and T cell-mediated nephritis.