Principal Investigators

Displaying 1 - 35 of 35
Name Research Area & Research interests Memberships
Ralf Baumeister's picture Ralf Baumeister
Institute of Biology III
Molecular Medicine

- Molecular genetics and biochemistry of aging and age-related diseases

CIBSS, SFB1381

Bertram Bengsch's picture Bertram Bengsch
Clinic for Internal Medicine II
Molecular Medicine

- Mechanisms of T cell exhaustion and tissue residency / Regulation of immune responses in Cancer, viral infection and autoimmunity / Immunometabolism / Systems immunology / Mass cytometry and imaging mass cytometry

CIBSS, EURIdoc

Christoph Borner's picture Christoph Borner
Institute for Molecular Medicine and Cell Research
Molecular Medicine

- Elucidation of the function of anti- and pro-apoptotic Bcl-2 family members / Characterization of components of RNA-virus (SFV)- and DNA-virus (HSV-1)-induced apoptosis signaling / Elucidation of the apoptotic and pro-inflammatory signaling pathways of the Aspergillus fumigatus toxin gliotoxin to prevent human Aspergillosis.

Priscilla Briquez's picture Priscilla Briquez
Dept. of General and Visceral Surgery, University Medical Center
Molecular Medicine

- We use protein engineering approaches to design novel drug delivery systems that target and modulate the immune response in inflamed tissues. Our research aims to develop or improve immunotherapies in cancer and regenerative medicine.

Tilman Brummer's picture Tilman Brummer
Institute of Molecular Medicine and Cell Research
Molecular Medicine

- Our main scientific interest is to understand the mechanisms by which cells convert the information of extracellular signals, e.g. hormones, growth factors or antigens, into intracellular signals and how these events steer physiological and pathological processes such as cancer.

Maria Stella Carro's picture Maria Stella Carro
Department of Neurosurgery, University Medical Center
Molecular Medicine

- My research focuses on the role and regulation of ZBTB18, a transcriptional repressor and tumor suppressor in the brain, which halts mesenchymal transformation of glioblastoma cells by counteracting key tumorigenic mechanisms such as fatty acid synthesis and the recruitment of pro-tumorigenic microglia.

Toni Cathomen's picture Toni Cathomen
Institute for Transfusion Medicine and Gene Therapy
Molecular Medicine

- Improvement of TALEN and CRISPR-Cas platforms for therapeutic applications in human stem cells / Development of disease models and cell therapies based on induced pluripotent stem cells (iPSCs) / Translation of cell and gene therapies for patients suffering from primary immunodeficiencies, HIV infection, and leukemia into the clinic.

Sven Diederichs's picture Sven Diederichs
Division of Cancer Research, Department of Thoracic Surgery, University Medical Center
Molecular Medicine

- Understanding molecular mechanisms of lung cancer and metastasis / Focus on RNA Biology and long non-coding RNAs / Approaches of Molecular Biology, Cell Biology & Bioinformatics

SFB1453

Miriam Erlacher's picture Miriam Erlacher
Center for Pediatrics and Adolescent Medicine, University Medical Center
Molecular Medicine

- Apoptosis signaling / Haematopoietic stem cell biology / Bone marrow failure / Myelodysplastic syndromes / Leukemia / Stem cell transplantation

Kilian Eyerich's picture Kilian Eyerich
Dept. of Dermatology and Venereology, University Medical Center
Molecular Medicine

- Inflammatory skin diseases, dermato-immunology, interaction of lymphocytes and resident skin cells, molecular classification.

Ian Frew's picture Ian Frew
Division of Hematology, Oncology and Stem Cell Transplantation, University Medical Center
Molecular Medicine

- Understanding how combinations of genetic mutations affect tumour phenotypes and responses to therapies / Development and use of novel genetic tools allowing high throughput genetics to model complex human tumours in mice / Genetic and chemical library screening to identify novel mutation-specific therapeuties

SFB1453

Tanja Hartmann's picture Tanja Hartmann
Clinic for Internal Medicine I, University Medical Center
Molecular Medicine

- Malignant and normal cell homing, microenvironment, cytoskeleton, integrins, leukemia.

Andreas Hecht's picture Andreas Hecht
Institute of Molecular Medicine and Cell Research
Molecular Medicine

- Invasion and metastasis in colorectal cancer using human cell lines and mouse intestinal organoids as model systems / Regulatory networks initiating and executing epithelial-mesenchymal transitions / Functional interplay of transcription factors and chromatin structure at cis-regulatory DNA elements

Lutz Hein's picture Lutz Hein
Institute of Experimental and Clinical Pharmacology and Toxicology, Department II
Molecular Medicine

- GPCR signaling in the cardiovascular system / Cell-type specific signaling mechanisms in the heart / Epigenetic mechanisms of physiological and pathological gene expression / Cardiovascular pharmacology

SFB1425

Tobias Hermle's picture Tobias Hermle
Department of Medicine, Renal Division, University Medical Center
Molecular Medicine

- Molecular mechanisms of genetic kidney diseases / Biology of the renal filtration barrier / Endocytosis and trafficking of the slit diaphragm protein nephrin / We combine human genetic analyses with animal models (Drosophila and mouse) and whole organism drug screening

SFB1453

Simone Hettmer's picture Simone Hettmer
University Medical Center
Molecular Medicine

- Research in our lab aims at a better understanding of cellular and molecular drivers of sarcoma initiation and maintenance through: i. characterization of the sarcoma-initiating capacities of mesodermal precursor cell populations; ii. investigation of the genetic basis of sarcoma susceptibility / Development of sarcoma test platforms in vitro and in mice

Ingo Hilgendorf's picture Ingo Hilgendorf
Department of Cardiology and Angiology I, UHZ
Molecular Medicine

- Identification of inflammatory processes responsible for the imbalanced immune response in atherosclerosis, myocardial infarction and other cardiovascular diseases / Defining feasible targets for immunomodulation to restore proper resolution of inflammation

SFB1425

Bernd Kammerer's picture Bernd Kammerer
Hilde Mangold Haus
Molecular Medicine

- Regulation of plant biochemical pathways to investigate central metabolism, biosynthesis of secondary metabolites, signalling and stress response / Metabolomics to unravel molecular mechanisms involved in Parkinson's disease and neurodegeneration / Biomarker identification in cancer / Analysis of the mitochondrial metabolome/ Metabolomics of prostate cancer.

Peter Kohl's picture Peter Kohl
Institute for Experimental Cardiovascular Medicine
Molecular Medicine

- Investigation of cardiac structure-function relations, using wet- and dry-lab techniques, with the aim of 'making better scars' in the heart.

CIBSS, SFB1425

Michael Köttgen's picture Michael Köttgen
Dept. of Internal Medicine IV, University Medical Center
Molecular Medicine

- Physiological and pathological functions of proteins involved in monogenic and complex genetic diseases, polycystic kidney disease, gout, TRP channels, calcium signaling, biology of cilia.

CIBSS, SFB1453

Anna Köttgen's picture Anna Köttgen
Institute of Genetic Epidemiology, University Medical Center
Molecular Medicine

- Genetic Epidemiology / Complex kidney and metabolic diseases / Transport mechanisms in the kidney / Monogenic kidney and solute transport diseases / Population-based studies / Pharmacogenomics / Use of genetic information for personalized health care, prevention.

CIBSS, SFB1453

Diana Lindner's picture Diana Lindner
Dept. of Cardiology and Angiology, UHZ
Molecular Medicine

- Pathophysiology of heart failure / mouse models with experimentally induced heart failure (e.g. myocardial infarction or viral myocarditis) / interplay of cardiac inflammation and fibrotic remodelling / in vitro cell culture experiments to elucidate the molecular mechanisms.

Ulrich Maurer's picture Ulrich Maurer
Institute of Molecular Medicine and Cell Research
Molecular Medicine

- Signaling of cell death and survival

Heike Pahl's picture Heike Pahl
Section of Molecular Hematology, Clinic for Internal Medicine I, University Medical Center
Molecular Medicine

- Molecular markers in Myeloproliferative Disorders / The role of transcription factor NF-E2 -Molecular etiology of NF-E2 and PRV-1 Overexpression in MPD / Molecular heterogeneity in Essential Thrombycythemia / Mouse models of myeloproliferative disorders

Sebastian Preissl's picture Sebastian Preissl
Institute of Experimental and Clinical Pharmacology and Toxicology
Molecular Medicine

- Epigenetic regulation of cardiovascular cell types / Transcriptional control of cardiovascular diseases / Molecular characterization of genetic variants / Single cell genomics, epigenomics, functional genomics

CIBSS, SFB1453

Michael Quante's picture Michael Quante
Clinic for Internal Medicine II, University Medical Center
Molecular Medicine

- Pathogenesis of Barrett's esophagus (BE) and the resulting adenocarcinoma of the esophagus (EAC)

Thomas Reinheckel's picture Thomas Reinheckel
Institute for Molecular Medicine and Cell Research
Molecular Medicine

- Involvement of proteolytic enzymes in cellular signalling processes concerning cancer and neurological diseases.

Eva Rog-Zielinska's picture Eva Rog-Zielinska
Institute for Experimental Cardiovascular Medicine
Molecular Medicine

- Structural and functional properties of atrial and ventricular T-tubules / Nano-to-micro scale investigation of the impact of mechanical activity on cardiac T-tubular system and other subcellular domains / Interactions between myocytes and non-myocytes in the heart (structural and functional) / Structural remodelling during heart disease and reverse remodelling

SFB1425

Christoph Schell's picture Christoph Schell
Institute of Surgical Pathology
Molecular Medicine

- Cell-matrix interactions in specialized renal epithelial cells (incldg. podocytes, proximal renal epithelial cells) / Characterization of key events modulating chronic interstitial fibrosis / Characterization and functional elucidation of the tumor matrisome in clear cell renal cell carcinoma (ccRCC) / Functional analysis of molecular subtypes of urothelial cell carcinoma

SFB1453

Oliver Schilling's picture Oliver Schilling
Institute of Surgical Pathology
Molecular Medicine

- We apply innovative proteomic and degradomic techniques to understand how proteolysis contributes to physiological and pathological processes. With over 560 proteases in man, this enzyme family ranks among the most abundant protein classes, illustrating its ubiquitous importance in human biology. We understand proteolysis as a post-translational modification that regulates protein location, function, and abundance.

SFB1453

Miriam Schmidts's picture Miriam Schmidts
Center for Pediatrics and Adolescent Medicine, University Medical Center
Molecular Medicine

- Gene discovery: the genetic basis of rare diseases with main focus on motile and non-motile ciliopathies, neurodevelopmental disorders and inherited renal diseases / Elucidating the molecular mechanisms underlying rare diseases using gene editing approaches in vitro and in vivo

CIBSS, SFB1453

Franziska Schneider-Warme's picture Franziska Schneider-Warme
Institute for Experimental Cardiovascular Medicine
Molecular Medicine

- Design and implementation of new optogenetic tools for modulating the activity of excitable cells and tissues / Development of optogenetic approaches for functionally dissecting electrical interactions between cardiac cell populations / Electrophysiological characterization of cardiac non-myocytes / 3D reconstruction of cellular networks in healthy and diseased hearts.

CIBSS, SFB1425

Marc Timmers's picture Marc Timmers
Centre for Clinical Research (ZKF), University Medical Center
Molecular Medicine

- Epigenetic control in cancer, Chromatin complexes, Histone modifications, Gene transcription. / Methods: genome-wide profiling, quantitative mass spectrometry, interaction proteomics, epigenetic drug screens.

SFB1453

Gerd Walz's picture Gerd Walz
Dept. of Internal Medicine IV, University Medical Center
Molecular Medicine

- Pathogenesis of renal cystic disease

CIBSS, SFB1453

Dennis Wolf's picture Dennis Wolf
Dept of Cardiology and Angiology, UHZ, University Medical Center
Molecular Medicine

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SFB1425